Choroidal Changes After Anti-VEGF Therapy in AMD Eyes With Different Types of Macular Neovascularization Using Swept-Source OCT Angiography.
Choroidal Changes After Anti-VEGF Therapy in AMD Eyes With Different Types of Macular Neovascularization Using Swept-Source OCT Angiography.
复制标题
抗VEGF治疗后，脉络膜变化在具有不同类型的黄斑新生血管形成的AMD眼睛中，使用扫描源OCT血管造影。
DOI：
10.1167/iovs.64.13.16
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发表时间：
2023-10-03
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
观察渗出型AMD患者抗血管内皮生长因子治疗前后的脉络膜改变，以确定黄斑新生血管(MNV)患者的脉络膜新生血管(MNV)与视网膜循环新生血管(MNV)之间的差异。对未经治疗的AMD患者进行扫描光源光学相干断层血管成像，扫描模式为12×12 mm。在抗血管内皮生长因子治疗前、治疗开始时和治疗后，测量中心凹中心5 mm和11 mm范围内的平均脉络膜厚度和脉络膜血管指数(CVI)。37例41只眼，其中1型24只眼，2型4只眼，3型13只眼。在5 mm和11 mm范围内，平均脉络膜厚度和CVI测量值从治疗前到渗出开始时逐渐增加(P≤0.0 3)。平均脉络膜厚度和CVI测量从渗出开始到治疗后都有所下降(P<；0.001)。治疗前后比较，平均脉络膜厚度和平均脉络膜厚度无明显变化(P>≥)。在1型或2型MNV眼与3型MNV眼之间，平均脉络膜厚度或CVI测量值没有显著差异。在治疗初治的AMD合并MNV的患者中，脉络膜厚度和血管在渗出开始时增加，然后在抗血管内皮生长因子治疗后减少。这一发现表明，这些脉络膜改变是在治疗前和治疗后对促血管生成环境的反应而发生的，与MNV的起源部位无关。
Choroidal changes before and after anti-VEGF therapy were investigated in eyes with exudative AMD to determine if there was a difference between eyes with macular neovascularization (MNV) that arises from the choroid (type 1 or 2) versus the retinal circulation (type 3). Patients with treatment-naïve AMD were imaged with swept-source optical coherence tomography angiography using a 12 × 12-mm scan pattern. The mean choroidal thickness and choroidal vascularity index (CVI) were measured within 5-mm and 11-mm fovea-centered circles before, at the onset of, and after anti-VEGF therapy. Forty-one eyes of 37 patients were included; 24 eyes with type 1 MNV, 4 eyes with type 2 MNV, and 13 eyes with type 3 MNV. Within the 5-mm and 11-mm circles, the mean choroidal thickness and CVI measurements increased from pretreatment to the onset of exudation (P ≤ 0.03). The mean choroidal thickness and CVI measurements decreased from the onset of exudation to after treatment (P < 0.001). No significant changes in mean choroidal thickness or CVI were observed when comparing measurements before or after treatment (P ≥ 0.38). No significant differences in mean choroidal thickness or CVI measurements were observed between eyes with type 1 or 2 MNV and type 3 MNV. In treatment-naïve AMD eyes with MNV, the choroidal thickness and vascularity increased at the onset of exudation and then decreased after anti-VEGF therapy. This finding suggests that these choroidal changes develop in response to the proangiogenic milieu before treatment and in response to treatment, regardless of the site of origin for the MNV.
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影响因子：
1.8
作者：
Hoenig, JM;Heisey, DM
通讯作者：
Heisey, DM
影响因子：
13.7
作者：
Li, Miaoling;Dolz-Marco, Rosa;Freund, K. Bailey
通讯作者：
Freund, K. Bailey
影响因子：
3
作者：
Pustejovsky, James E.;Tipton, Elizabeth
通讯作者：
Tipton, Elizabeth
影响因子：
1
作者：
Motulsky, Elie H.;Zheng, Fang;Rosenfeld, Philip J.
通讯作者：
Rosenfeld, Philip J.
DOI：
10.1161/hypertensionaha.117.10271
发表时间：
2018-03
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Pandey AK;Singhi EK;Arroyo JP;Ikizler TA;Gould ER;Brown J;Beckman JA;Harrison DG;Moslehi J
通讯作者：
Moslehi J