Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats
Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats
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DOI：
10.1007/s00213-012-2663-7
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发表时间：
2012-08-01
影响因子：
3.4
通讯作者：
France, Charles P.
中科院分区：
文献类型：
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作者：
Baladi, Michelle G.;Koek, Wouter;France, Charles P.
多巴胺系统在发育过程中会发生变化，从而影响作用于这些系统的药物。饮食因素也会影响药物对多巴胺系统的作用。本研究考察了摄入高脂肪食物是否会改变可卡因（1-56 mg/kg）对青春期和成年雌性大鼠的运动影响。在大鼠（n = 6/组）中研究可卡因，这些大鼠可自由进食标准（5.7%脂肪）或高脂肪（34.3%）食物，或限制进食高脂肪食物（体重与进食标准食物的大鼠相符）。在食用高脂食物（自由或限制进食）1周后，与食用标准食物的大鼠相比，青春期和成年大鼠对可卡因的敏感性显著增加。青春期大鼠对可卡因的敏感性也增加了，这些大鼠在4周内限制而不是自由地获得高脂肪食物。当先前吃高脂肪食物的青春期和成年大鼠吃标准食物时，对可卡因的敏感性恢复正常。在食用高脂肪食物（而非食用标准食物）的青春期和成年雌性大鼠中，对可卡因的敏感性在每周一次的可卡因试验中逐渐增加（即致敏），这种方式在青少年和成年之间没有统计学差异。这些结果表明，食用高脂肪食物改变了雌性大鼠对急性给药可卡因的敏感性，也促进了对可卡因敏感的发展。食用的食物种类会增加药物的作用，这可能与女性易受可卡因滥用的影响有关。
Dopamine systems vary through development in a manner that can impact drugs acting on those systems. Dietary factors can also impact the effects of drugs acting on dopamine systems.This study examined whether eating high fat chow alters locomotor effects of cocaine (1-56 mg/kg) in adolescent and adult female rats.Cocaine was studied in rats (n = 6/group) with free access to standard (5.7% fat) or high fat (34.3%) chow or restricted access to high fat chow (body weight matched to rats eating standard chow).After 1 week of eating high fat chow (free or restricted access), sensitivity to cocaine was significantly increased in adolescent and adult rats, compared with rats eating standard chow. Sensitivity to cocaine was also increased in adolescent rats with restricted, but not free, access to high fat chow for 4 weeks. When adolescent and adult rats that previously ate high fat chow ate standard chow, sensitivity to cocaine returned to normal. In adolescent and adult female rats eating high fat chow, but not those eating standard chow, sensitivity to cocaine increased progressively over once weekly tests with cocaine (i.e., sensitization) in a manner that was not statistically different between adolescents and adults.These results show that eating high fat chow alters sensitivity of female rats to acutely administered cocaine and also facilitates the development of sensitization to cocaine. That the type of food consumed can increase drug effects might have relevance to vulnerability to abuse cocaine in the female population.