MicroRNAs and Cardiac Regeneration.
MicroRNAs and Cardiac Regeneration.
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microRNA和心脏再生。
DOI：
10.1161/circresaha.116.304377
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发表时间：
2015-05-08
影响因子：
20.1
通讯作者：
Dzau VJ
中科院分区：
文献类型：
--
作者：
Hodgkinson CP;Kang MH;Dal-Pra S;Mirotsou M;Dzau VJ
人类心脏在心脏损伤后再生丢失或受损的心肌细胞的能力非常有限。相反，心肌损伤的特点是成纤维细胞进行广泛的心脏重塑，最终导致心脏结构和功能恶化。如果这些成纤维细胞能够转化为心肌细胞，心脏功能将会得到改善。 MicroRNA (miRNA) 是一种促进 mRNA 降解和抑制 mRNA 翻译的小型非编码 RNA，已被证明在心脏发育中发挥着重要作用。利用这些信息，不同的研究人员通过多种方法利用 miRNA 来促进心肌细胞的形成。几种 miRNA 联合作用可促进心脏成纤维细胞直接转化为心肌细胞。此外，已经鉴定出许多有助于 iPS 细胞形成的 miRNA，并且 miRNA 还诱导这些细胞采取心脏命运。 miRNA 也与常驻心脏祖细胞分化有关。在这篇综述中，我们将讨论与这些过程相关的当前文献，并讨论这些发现的治疗意义。
The human heart has a very limited capacity to regenerate lost or damaged cardiomyocytes following cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function. Cardiac function would be improved if these fibroblasts could be converted into cardiomyocytes. MicroRNAs (miRNAs), small non-coding RNAs that promote mRNA degradation and inhibit mRNA translation, have been shown to be important in cardiac development. Using this information various researchers have utilized miRNAs to promote the formation of cardiomyocytes through a number of approaches. Several miRNAs acting in combination promote the direct conversion of cardiac fibroblasts into cardiomyocytes. Moreover, a number of miRNAs have been identified that aid the formation of iPS cells and miRNAs also induce these cells to adopt a cardiac fate. MiRNAs have also been implicated in resident cardiac progenitor cell differentiation. In this review we will discuss the current literature as it pertains to these processes as well as discussing the therapeutic implications of these findings.