Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
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DOI：
10.1007/s00125-006-0190-y
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发表时间：
2006-05-01
期刊：
影响因子：
8.2
通讯作者：
Kolb, H
中科院分区：
文献类型：
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作者：
Herder, C;Baumert, J;Kolb, H
趋化因子单核细胞趋化蛋白-1(MCP-1)、白介素8(IL-8)和干扰素-γ诱导蛋白-10(IP-10)由脂肪细胞释放，可能与动脉粥样硬化有关。我们假设这些趋化因子可能是2型糖尿病发展的危险因素。采用病例队列设计，基于奥格斯堡地区基于人群的心血管疾病趋势和决定因素监测(MONICA)/德国奥格斯堡地区合作健康研究(KORA Augsburg)的数据，分析了526名2型糖尿病患者和1,695名未发生2型糖尿病的患者的基线趋化因子水平。平均随访时间为10.8年。单核细胞趋化蛋白-1与2型糖尿病相关，在很大程度上独立于经典危险因素，而各种临床和代谢参数以及生活方式因素是IL-8和IP-10与2型糖尿病关联的主要混杂因素。进一步调整C-反应蛋白(CRP)和IL-6对观察到的相关性没有影响。三种趋化因子(MCP-1、IL-8和IP-10)均高于各自中位数的受试者与所有趋化因子均低于或等于中位数的受试者相比，危险比(HR)为1.79(95%CI为1.18~2.72)，与合并CRP和IL-6升高的HR(调整了年龄、性别、调查、BMI、收缩压、总胆固醇：高密度脂蛋白胆固醇比率、体力活动、饮酒、吸烟和父母糖尿病病史)相当。虽然IL-8和IP-10与糖尿病的关联通过多变量调整而减弱，但高MCP-1水平独立于先前描述的临床、代谢和免疫风险因素而导致糖尿病风险。
The chemokines monocyte chemoattractant protein-1 (MCP-1), IL-8 and interferon-gamma-inducible protein-10 (IP-10) are released by adipocytes and appear to be involved in atherosclerosis. We hypothesised that these chemokines may be risk factors for the development of type 2 diabetes.Using a case-cohort design based on data from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Kooperative Gesundheitsforschung in der Region Augsburg/Cooperative Health Research in the Region of Augsburg (KORA Augsburg) study, chemokine levels at baseline were analysed in 526 individuals with and 1,695 individuals without incident type 2 diabetes. The mean follow-up time was 10.8 years.MCP-1 was associated with type 2 diabetes, largely independently of classic risk factors, whereas various clinical and metabolic parameters as well as lifestyle factors were major confounders of the association of IL-8 and IP-10 with type 2 diabetes. Further adjustment for C-reactive protein (CRP) and IL-6 had no impact on the observed associations. The hazard ratio (HR) for subjects with systemic concentrations of all three chemokines (MCP-1, IL-8 and IP-10) above the respective median compared with those with all chemokines below or equal to the median was 1.79 (95% CI 1.18-2.72) and was comparable with the HR for elevated CRP and IL-6 together (adjusted for age, sex, survey, BMI, systolic blood pressure, total cholesterol:HDL cholesterol ratio, physical activity, alcohol intake, smoking and parental history of diabetes).Elevated concentrations of MCP-1, IL-8 and IP-10 are associated with incident type 2 diabetes. Whereas the association of IL-8 and IP-10 with diabetes was attenuated by multivariable adjustment, high MCP-1 levels contributed to diabetes risk independently of previously described clinical, metabolic and immunological risk factors.