Anchoring α-cyclodextrin-based polyrotaxanes to biological tissues via riboflavin-mediated photo-crosslinking
Anchoring α-cyclodextrin-based polyrotaxanes to biological tissues via riboflavin-mediated photo-crosslinking
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DOI：
10.1016/j.matlet.2021.129460
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发表时间：
2021-02-17
影响因子：
3
通讯作者：
Yui, Nobuhiko
中科院分区：
文献类型：
--
作者：
Arisaka, Yoshinori;Yui, Nobuhiko
本研究通过核黄素（RBFs）设计了光交联聚轮烷（PRXs），用于锚定生物组织。特别地，我们合成了带氨基的PRXs，在PRXs中，多个带氨基的α -环糊精（α - cds）被连接到末端以金刚烷分子为末端的聚乙二醇链上。含>= 33个氨基的PRXs在rbf存在下经UV-A光照射后交联形成水凝胶。凝胶化时间最短约15分钟。PRX水凝胶对小鼠成纤维细胞具有良好的粘附和扩散能力。此外，当光交联在猪主动脉表面作为模型组织时，具有氨基的prx强烈地锚定在组织上。此外，具有氨基的PRXs被证实可以成功关闭组织中的切口。因此，光交联prx可以作为基于超分子的组织粘附生物材料用于修复和再生生物组织。(C) 2021 Elsevier B.V.版权所有
In the present study, photo-crosslinkable polyrotaxanes (PRXs) via riboflavins (RBFs) were designed for anchoring to biological tissues. In particular, PRXs with amino groups, in which multiple alpha-cyclodextrins (alpha-CDs) with amino groups were threaded onto a poly(ethylene glycol) chain endcapped with adamantane molecules, were synthesized. PRXs with >= 33 amino groups were crosslinked to form hydrogels after irradiation with UV-A light in the presence of RBFs. The time for gelation was approximately 15 min at the shortest. The PRX hydrogels showed excellent adhesion and spreading of mouse fibroblasts. Furthermore, when photo-crosslinking on a surface of porcine aorta as model tissues, the PRXs with amino groups strongly anchored to the tissues. Additionally, the PRXs with amino groups were confirmed to successfully close an incision in the tissues. Thus, photo-crosslinkable PRXs may be applied as supermolecule-based tissue adhesive biomaterials for repairing and regenerating biological tissues. (C) 2021 Elsevier B.V. All rights reserved.