Association of Parental Hypertension With Arterial Stiffness in Nonhypertensive Offspring: The Framingham Heart Study.
Association of Parental Hypertension With Arterial Stiffness in Nonhypertensive Offspring: The Framingham Heart Study.
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DOI：
10.1161/hypertensionaha.116.07426
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Vasan RS
中科院分区：
文献类型：
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作者：
Andersson C;Quiroz R;Enserro D;Larson MG;Hamburg NM;Vita JA;Levy D;Benjamin EJ;Mitchell GF;Vasan RS
High arterial stiffness appears to be causally involved in the pathogenesis of hypertension. We tested the hypothesis that offspring of parents with hypertension may display higher arterial stiffness prior to clinically manifest hypertension, given that hypertension is a heritable condition. We compared arterial tonometry measures in a sample of 1564 non-hypertensive Framingham Heart Study Third generation cohort participants (mean age 38 years, 55% women) whose parents were enrolled in the Framingham Offspring Study. A totally of 468, 715, and 381 participants had 0 (referent), 1, and 2 parents with hypertension. Parental hypertension was associated with greater offspring mean arterial pressure (multivariable-adjusted estimate= 2.9 mm Hg, 95% confidence interval [CI] 1.9-3.9, and 4.2 mm Hg, 95% CI 2.9-5.5, for 1 and 2 parents with hypertension, respectively, p<0.001 for both), and with greater forward pressure wave amplitude (1.6 mm Hg, 95% CI 0.6-2.7, and 1.9 mm Hg, 95% CI 0.6-3.2, for 1 and 2 parents with hypertension, respectively, p=0.003 for both). Carotid-femoral pulse wave velocity and augmentation index displayed similar dose-dependent relations with parental hypertension in sex, age, and height-adjusted models, but associations were attenuated upon further adjustment. Offspring with at least one parent in the upper quartile of augmentation index and carotid-femoral pulse wave velocity had significantly higher values themselves (p≤0.02). In conclusion, in this community-based sample of young, non-hypertensive adults, we observed greater arterial stiffness in offspring of parents with hypertension. These observations are consistent with higher vascular stiffness at an early stage in the pathogenesis of hypertension.
