Epithelial-Mesenchymal Transition in tumor microenvironment.
Epithelial-Mesenchymal Transition in tumor microenvironment.
复制标题
肿瘤微环境中的上皮-间质转化
DOI：
10.1186/2045-3701-1-29
复制
发表时间：
2011-08-31
影响因子：
7.5
通讯作者：
Wei L
中科院分区：
文献类型：
--
作者：
Jing Y;Han Z;Zhang S;Liu Y;Wei L
上皮细胞向间充质细胞的转化（EMT）在机体计划的形成和肿瘤侵袭过程中起着至关重要的作用。此外，EMT还会导致细胞粘附性破坏、尖基极性丧失、基质重塑、运动性增强和侵袭性增强，从而促进肿瘤转移。肿瘤微环境在促进肿瘤转移中起着重要作用，并可能诱导肿瘤细胞发生EMT。大量炎性细胞浸润肿瘤部位，肿瘤大面积存在缺氧，再加上肿瘤微环境中存在多种干细胞，如肿瘤干细胞（cancer stem cells, CSCs）、间充质干细胞（mesenchymal stem cells, MSCs），这些都可能是肿瘤细胞EMT的诱导剂。EMT参与的信号通路多种多样，包括TGF-β、NF-κB、Wnt、Notch等。在这篇综述中，我们讨论了肿瘤微环境在EMT中的作用以及相关的信号通路以及它们之间的相互作用。
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and also in the tumor invasion process. In addition, EMT also causes disruption of cell-cell adherence, loss of apico-basal polarity, matrix remodeling, increased motility and invasiveness in promoting tumor metastasis. The tumor microenvironment plays an important role in facilitating cancer metastasis and may induce the occurrence of EMT in tumor cells. A large number of inflammatory cells infiltrating the tumor site, as well as hypoxia existing in a large area of tumor, in addition many stem cells present in tumor microenvironment, such as cancer stem cells (CSCs), mesenchymal stem cells (MSCs), all of these may be the inducers of EMT in tumor cells. The signaling pathways involved in EMT are various, including TGF-β, NF-κB, Wnt, Notch, and others. In this review, we discuss the current knowledge about the role of the tumor microenvironment in EMT and the related signaling pathways as well as the interaction between them.
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