Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging.
Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging.
复制标题
阿尔茨海默病遗传学和 C 反应蛋白对衰老认知能力的独立作用。
DOI：
10.1016/j.neurobiolaging.2023.02.006
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发表时间：
2023
影响因子：
4.2
通讯作者：
Kauppi,Karolina
中科院分区：
文献类型：
--
作者：
Supiyev,Adil;Karlsson,Robert;Wang,Yunzhang;Koch,Elise;Hägg,Sara;Kauppi,Karolina
Apolipoprotein E (APOE)ε4, the strongest genetic risk factor for late onset Alzheimer's disease (LOAD), has been associated with cognitive decline independent from AD pathology, but the role for other LOAD risk genes in normal cognitive aging is less studied. We examined the effect ofAPOE ε4and several different polygenic risk scores (PRS) for LOAD on cognitive level and decline in aging, using longitudinal data from the UK Biobank. While PRS-LOAD including all variants (exceptAPOE)predicted cognitive level,APOE ε4and PRS-LOAD based on 17 non-APOEgene variants with strong association to AD (p< 5e-8) predicted age-related decline in verbal numeric reasoning. The effect on decline were partly driven by 4 variants involved in the immune system. Those variants also predicted serum levels of the inflammatory marker C-reactive protein (CRP), but CRP did not mediate the effect on decline. Those findings suggest genetic variations in immune functions play a role in aspects of cognitive aging that may be independent of LOAD pathology as well as systemic inflammation measured by CRP.
