Time Delay Induces Resonant Activation in Intracellular Calcium Oscillations
Time Delay Induces Resonant Activation in Intracellular Calcium Oscillations
复制标题
时间延迟诱导细胞内钙振荡的共振激活
DOI：
10.6122/cjp.52.1059
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发表时间：
2014-06
影响因子：
5
通讯作者：
Duan, Peng-Fei
中科院分区：
文献类型：
--
作者：
Duan, Wei-Long;Duan, Peng-Fei
利用一阶随机模拟算法，研究了细胞内钙离子有色噪声主动传递过程的时延对细胞内钙振荡(ICO)的影响。通过模拟ICO系统的时间序列和平稳概率分布，发现随着时滞和有色噪声的增加，周期性分别被增强和破坏；随着时滞的变化，出现双稳态和单稳态。然后，从系统从SPD的次峰到主峰的平均第一通过时间(MFPT)的统计结果表明：随着有色噪声的增强，时间延迟在ICO系统中诱导了共振激活(RA)。
The role of time delay of the active transmission processes with colored noises of the intracellular Ca^(2+) on the intracellular calcium oscillation (ICO) is investigated by means of a first-order stochastic simulation algorithm. By simulating the time series and stationary probability distribution (SPD) of the ICO system, as the time delay and colored noises increase periodicity is respectively strengthened and destroyed; bistable and monostable states appear as the time delay varies. Then, from the statistics of the mean first-passage time (MFPT) of the system from the secondary peak to the main peak of the SPD, the results indicate: as colored noises strengthen, time delay induces a resonant activation (RA) in the ICO system.