A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
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DOI：
10.1016/s0014-5793(97)00984-8
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发表时间：
1997-09-08
期刊：
影响因子：
3.5
通讯作者：
Oster, G
中科院分区：
文献类型：
--
作者：
Glick, BS;Elston, T;Oster, G
形态学数据表明，高尔基体池形成在顺式面的堆栈，然后逐步成熟为trans-cisterteries。然而，其他研究表明，COPI囊泡在高尔基池之间运输物质，这两个观察结果可以通过假设池在顺行方向上通过堆叠携带分泌物而协调，而COPI囊泡在逆行方向上运输高尔基酶。该模型提供了池成熟的机制，如果高尔基酶相互竞争包装成COPI囊泡，我们可以解释酶在整个堆叠中的不对称分布。(C)1997年欧洲生物化学学会联合会。
Morphological data suggest that Golgi cisternae form at the cis-face of the stack and then progressively mature into trans-cisternae. However, other studies indicate that COPI vesicles transport material between Golgi cisternae, These two observations can be reconciled by assuming that cisternae carry secretory cargo through the stack in the anterograde direction, while COPI vesicles transport Golgi enzymes in the retrograde direction, This model provides a mechanism for cisternal maturation, If Golgi enzymes compete,vith one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack. (C) 1997 Federation of European Biochemical Societies.