Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions
Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions
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DOI：
10.1021/cm100023p
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发表时间：
2010-08-24
影响因子：
8.6
通讯作者：
Epple, M.
中科院分区：
文献类型：
--
作者：
Kittler, S.;Greulich, C.;Epple, M.
通过在 5、25 和 37 摄氏度下透析长达 125 天，研究了柠檬酸盐稳定和聚（乙烯基吡咯烷酮）稳定的银纳米颗粒在水中的溶解情况。颗粒在几天的时间内缓慢溶解成离子。然而，在所有情况下，都观察到释放的银的极限值，即颗粒没有完全溶解。在某些情况下，纳米颗粒释放出其重量的 90%。计算正式的动力学数据。溶解速率和程度取决于官能化以及储存温度。由于银离子浓度增加，银的释放导致分散储存数周的银纳米颗粒对人间充质干细胞的毒性显着增加。因此，“老化的”（即浸没的）银纳米颗粒对细胞的毒性比新制备的银纳米颗粒大得多。
The dissolution of citrate-stabilized and poly(vinylpyrrolidone)-stabilized silver nanoparticles in water was studied by dialysis for up to 125 days at 5, 25, and 37 degrees C. The particles slowly dissolve into ions on a time scale of several days. However, in all cases, a limiting value of the released silver was observed, i.e., the particles did not completely dissolve. In some cases, the nanoparticles released up to 90% of their weight. Formal kinetic data were computed. Rate and degree of dissolution depended on the functionalization as well as on the storage temperature. The release of silver led to a considerably increased toxicity of silver nanoparticles which had been stored in dispersion for several weeks toward human mesenchymal stem cells due to the increased concentration of silver ions. Consequently, "aged" (i.e., immersed) silver nanoparticles are much more toxic to cells than freshly prepared silver nanoparticles.