Family and twin studies in inflammatory bowel disease
Family and twin studies in inflammatory bowel disease
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DOI：
10.3748/wjg.v12.i23.3668
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发表时间：
2006-06-21
影响因子：
4.3
通讯作者：
Kontula, Kimmo
中科院分区：
文献类型：
--
作者：
Halme, Leena;Paavola-Sakki, Paulina;Kontula, Kimmo
检查不同家族中炎症性肠病 (IBD) 遗传的研究是 IBD 遗传学最新分子进展的基础。克罗恩病 (CD) 的衍生遗传力高于许多其他复杂疾病。 CD先证者的一级亲属患IBD的风险最高，但患有溃疡性结肠炎（UC）的先证者的一级亲属和更远的亲属的风险也更高。 IBD 疾病一致性率已在多重家庭和三项大型欧洲双胞胎研究中进行了检查。 (c) 2006 年 WJG 出版社。版权所有。
Studies examining the inheritance of inflammatory bowel disease (IBD) within different family groups have been the basis for recent molecular advances in the genetics of IBD. The derived heritability in Crohn's disease (CD) is higher than in many other complex diseases. The risk of IBD is highest in first-degree relatives of a CD proband, but first-degree relatives of a proband suffering from ulcerative colitis (UC) and more distant relatives are also at increased risk. Disease concordance rates in IBD have been examined in multiplex families and in three large European twin studies. (c) 2006 The WJG Press. All rights reserved.