EFFECTS OF VIITH (FACIAL) NERVE DEGENERATION ON VASOACTIVE INTESTINAL POLYPEPTIDE AND SUBSTANCE-P LEVELS IN OCULAR AND ORBITAL TISSUES OF THE RABBIT
EFFECTS OF VIITH (FACIAL) NERVE DEGENERATION ON VASOACTIVE INTESTINAL POLYPEPTIDE AND SUBSTANCE-P LEVELS IN OCULAR AND ORBITAL TISSUES OF THE RABBIT
复制标题
DOI：
10.1016/0014-4835(84)90052-6
复制
发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
BLOOM, SR
中科院分区：
文献类型：
--
作者：
BUTLER, JM;RUSKELL, GL;BLOOM, SR
本文测定了白化病兔眼和眶组织中血管活性肠肽（VIP）和P物质（SP）样免疫反应性的水平。在脉络膜中检测到大量的VIP（22.6 ± 0.01）。3.6 pmol/g）和泪腺（13.6 ±. 4.4 pmol/g）和哈氏腺（20.2 . ±. 4.9 pmol/g）。在前葡萄膜（3.6 . ±. 1.1 pmol/g）、视网膜（5.4 ±. 1.3 pmol/g）和视神经乳头（4.1 . ±. 1.1 pmol/g）。其他组织，包括结膜和眼外肌显示非常少的VIP样免疫反应性。在对翼腭神经节区域的透热损伤后7天，VIP几乎从所有这些组织中消除。SP水平也降低，特别是在前葡萄膜，可能是由于同时破坏的感觉纤维。电镜下可见睫状短神经和脉络膜内无髓轴突广泛变性。交感神经切断后，虽然在前葡萄膜中观察到SP的显著升高，但未检测到眼VIP水平的变化。视网膜VIP的减少被认为局限于无长突细胞，被认为是术后眼睑闭合的结果，而不是第7神经变性的结果。除此之外，兔眼和眼眶组织中的VIP似乎仅包含在面神经起源的副交感神经纤维中。
Levels of vasoactive intestinal polypeptide (VIP)- and substance P (SP)=like immunoreactivity were measured in ocular and orbital tissues of albino rabbits. Substantial amounts of VIP were detected in the choroid (22.6 .+-. 3.6 pmol/g) and in lacrimal (13.6 .+-. 4.4 pmol/g) and Harderian glands (20.2 .+-. 4.9 pmol/g). Somewhat less was found in the anterior uvea (3.6 .+-. 1.1 pmol/g), retina (5.4 .+-. 1.3 pmol/g) and optic nerve head (4.1 .+-. 1.1 pmol/g). Other tissues, including conjunctiva and extraocular muscle showed very little VIP-like immunoreactivity. Seven days after diathermic damage to the region of the pterygopalatine ganglion VIP was virtually eliminated from all these tissues. SP levels were also reduced, notably in the anterior uvea, probably due to concurrent destruction of sensory fibers. EM revealed extensive degeneration of unmyelinated axons in the short ciliary nerves and in the choroid. No changes in ocular VIP levels were detected after sympathetic denervation, although a significant rise in SP was observed in the anterior uvea. The decrease in retinal VIP, believed to be confined to the amacrine cells, is considered to be a result of postoperative lid closure, rather than of 7th nerve degeneration. With this exception, VIP in ocular and orbital tissues of the rabbit appears to be contained exclusively within parasympathetic fibers of facial nerve origin.