Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB A case-control study
Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB A case-control study
复制标题
DOI：
10.1212/wnl.0b013e3181e7b66e
复制
发表时间：
2010-07-13
期刊：
影响因子：
9.9
通讯作者：
Clifford, D. B.
中科院分区：
文献类型：
--
作者：
Ances, B. M.;Christensen, J. J.;Clifford, D. B.
目的：在老年HIV感染（HIV+）个体中区分HIV痴呆和阿尔茨海默病（AD）存在诊断挑战。类似的脑淀粉样蛋白- β 42 （A β 42）代谢异常可能与hiv相关的神经病理和AD有关。我们评估了淀粉样蛋白结合剂c -11-匹兹堡化合物B (C-11-PiB)，这是一种a β 42沉积的生物标志物，在认知功能未受损的HIV+ (n = 10)参与者和匹配的无痴呆社区对照（n = 20）中。方法：在这项病例对照研究中，所有参与者在2年内进行了脑脊液研究和神经心理测试的C-11-PiB扫描。通过chi(2)检验评估HIV+和社区对照在人口学和临床价值方面的统计差异。参与者被进一步分为低（= 500 pg/mL） CSF A β 42组，并进行学生t检验，以确定纤维样淀粉样斑块沉积的区域差异是否随CSF A β 42而变化。结果：无论CSF A β 42水平如何，通过增加的C-11-PiB平均皮质结合电位（MCBP）或4个皮质区域的结合电位来评估，没有HIV阳性参与者出现纤维样淀粉样斑块。相比之下，一些社区对照组在皮质区域具有低CSF A β 42（0.18任意单位）。结论：认知功能未受损的HIV+参与者，即使CSF A β 42 (
Objectives: Diagnostic challenges exist for differentiating HIV dementia from Alzheimer disease (AD) in older HIV-infected (HIV+) individuals. Similar abnormalities in brain amyloid-beta 42 (A beta 42) metabolism may be involved in HIV-associated neuropathology and AD. We evaluated the amyloid-binding agent C-11-Pittsburgh compound B (C-11-PiB), a biomarker for A beta 42 deposition, in cognitively unimpaired HIV+ (n = 10) participants and matched community controls without dementia (n = 20).Methods: In this case-control study, all participants had an C-11-PiB scan within 2 years of concomitant CSF studies and neuropsychometric testing. Statistical differences between HIV+ and community controls for demographic and clinical values were assessed by chi(2) tests. Participants were further divided into either low (= 500 pg/mL) CSF A beta 42 groups with Student t tests performed to determine if regional differences in fibrillar amyloid plaque deposition varied with CSF A beta 42.Results: Regardless of CSF A beta 42 level, none of the HIV+ participants had fibrillar amyloid plaques as assessed by increased C-11-PiB mean cortical binding potential (MCBP) or binding potential within 4 cortical regions. In contrast, some community controls with low CSF A beta 42 (0.18 arbitrary units) within cortical regions.Conclusions: Cognitively unimpaired HIV+ participants, even with low CSF A beta 42 (