HER2 expression beyond breast cancer: therapeutic implications for gynecologic malignancies.
HER2 expression beyond breast cancer: therapeutic implications for gynecologic malignancies.
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DOI：
10.1007/s40291-013-0024-9
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发表时间：
2013-04
影响因子：
4
通讯作者：
Santin, Alessandro D.
中科院分区：
文献类型：
--
作者：
English, Diana P.;Roque, Dana M.;Santin, Alessandro D.
HER 2或ErbB 2是表皮生长因子家族的成员，在乳腺癌、卵巢癌、胃癌、结直肠癌、胰腺癌和子宫内膜癌的亚群中过表达。HER 2通过与细胞存活和增殖相关的几种途径（Ras/Raf/促分裂原活化蛋白激酶和磷脂酰肌醇-3激酶/蛋白激酶-B/哺乳动物雷帕霉素靶点途径）调节信号传导。HER 2过表达和/或基因扩增的肿瘤通常被认为是生物侵袭性肿瘤。在乳腺癌、宫颈癌、子宫内膜癌和卵巢癌中，有几项研究将c-erbB 2基因扩增与化疗耐药性和总体生存率低下联系起来。酪氨酸激酶抑制剂和靶向HER 2的单克隆抗体的免疫治疗为患有这些侵袭性肿瘤的患者带来了希望。曲妥珠单抗联合细胞毒性化疗药物或与放射性同位素结合目前正在几种肿瘤类型的临床试验中进行研究。
HER2 or ErbB2 is a member of the epidermal growth factor family and is overexpressed in subsets of breast, ovarian, gastric, colorectal, pancreatic and endometrial cancers. HER2 regulates signaling through several pathways (Ras/Raf/mitogen-activated protein kinase and phosphatidylinositol-3 kinase/protein kinase-B/mammalian target of rapamycin pathways) associated with cell survival and proliferation. HER2 overexpressed and/or gene amplified tumors are generally regarded as biologically aggressive neoplasms. In breast, cervical, endometrial and ovarian cancer, there have been several studies linking the amplification of the c-erbB2 gene with chemo-resistance and overall poor survival. Tyrosine kinase inhibitors and immunotherapy with monoclonal antibodies targeting HER2 holds promise for patients harboring these aggressive neoplasms. Trastuzumab combined with cytotoxic chemotherapy agents or conjugated with radioactive isotopes is currently being investigated in clinical trials of several tumor types.
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