Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas.
Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas.
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预后营养指数作为消化系统癌症生存的预后生物标志物
DOI：
10.18632/oncotarget.13472
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发表时间：
2016-12-27
期刊：
影响因子：
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通讯作者：
Dai Z
中科院分区：
文献类型：
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作者：
Zhao Y;Xu P;Kang H;Lin S;Wang M;Yang P;Dai C;Liu X;Liu K;Zheng Y;Dai Z
预后营养指数（PNI）已被报道与各种恶性肿瘤患者的预后相关。我们进行了一项荟萃分析，以确定PNI在消化系统癌症中的预测潜力。这项荟萃分析涉及23项研究，共7384名消化系统癌患者。PNI越低，总生存期（OS）越短[危险比（HR） 1.83, 95%可信区间（CI） 1.62-2.07]，无病生存期（DFS）越差（HR 1.85, 95% CI 1.19-2.89），术后并发症发生率越高（HR 2.31, 95% CI 1.63-3.28）。综上所述，PNI可作为判断消化系统癌患者预后的有效指标。
The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62–2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19–2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63–3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.