Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models.
Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models.
复制标题
慢性阻塞性肺疾病免疫反应中的中性粒细胞炎症：动物模型的教训
DOI：
10.1155/2017/7915975
复制
发表时间：
2017
影响因子：
4.1
通讯作者：
Chen ZH
中科院分区：
文献类型：
--
作者：
Huang G;Xu XC;Zhou JS;Li ZY;Chen HP;Wang Y;Li W;Shen HH;Chen ZH
慢性阻塞性肺疾病（COPD）是世界范围内死亡的主要原因，其特征在于慢性支气管炎、小气道的破坏和肺泡的扩大/解体。普遍认为，在COPD患者的肺部中观察到的嗜酸性气道炎症与组织破坏和肺泡气腔扩大内在相关，导致疾病进展。动物模型在研究COPD的潜在机制中起着重要作用，因为它们解决了涉及整体全身反应的问题。本文就目前COPD动物模型的研究进展进行综述，重点介绍各种模型在免疫反应和嗜酸性炎症方面的优缺点。此外，我们提出了一种潜在的新的COPD动物模型，它可能模仿人类COPD发病机制的最大特征，包括持续的中度至高度的嗜酸性炎症。
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, which is characterized by chronic bronchitis, destruction of small airways, and enlargement/disorganization of alveoli. It is generally accepted that the neutrophilic airway inflammation observed in the lungs of COPD patients is intrinsically linked to the tissue destruction and alveolar airspace enlargement, leading to disease progression. Animal models play an important role in studying the underlying mechanisms of COPD as they address questions involving integrated whole body responses. This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation. Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.