Modulating behavioral inhibition by tDCS combined with cognitive training
Modulating behavioral inhibition by tDCS combined with cognitive training
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DOI：
10.1007/s00221-012-3098-4
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发表时间：
2012-06-01
影响因子：
2
通讯作者：
Lavidor, Michal
中科院分区：
文献类型：
--
作者：
Ditye, Thomas;Jacobson, Liron;Lavidor, Michal
认知训练是改善各种认知功能的有效工具，现在有少数研究表明，伴随这些训练方案的大脑刺激可以增强其效果。在行为抑制领域，人们对训练如何影响这种技能知之甚少。至于经颅直流电刺激（tDCS），以前发现，刺激右额下回（rIFG）促进行为抑制性能和调节其电生理相关。本研究旨在研究这种行为促进的学习范式的背景下，通过给予tDCS超过rIFG重复超过连续四天的训练的行为抑制任务（停止信号任务（SST））。22名参与者参与; 10名参与者被分配接受阳极tDCS（1.5 mA，15 min），12名参与者被分配接受训练但不接受主动刺激。训练对SST的学习和表现有显著影响，训练和rIFG-tDCS的整合产生了更线性的学习斜率。主动刺激组的表现也更好。我们的研究结果表明，tDCS结合认知训练是提高抑制反应能力的有效工具。目前的研究可能是朝着使用tDCS和认知训练作为治疗注意力缺陷多动障碍（ADHD）或精神分裂症等疾病中认知控制障碍的治疗工具迈出的一步。
Cognitive training is an effective tool to improve a variety of cognitive functions, and a small number of studies have now shown that brain stimulation accompanying these training protocols can enhance their effects. In the domain of behavioral inhibition, little is known about how training can affect this skill. As for transcranial direct current stimulation (tDCS), it was previously found that stimulation over the right inferior frontal gyrus (rIFG) facilitates behavioral inhibition performance and modulates its electrophysiological correlates. This study aimed to investigate this behavioral facilitation in the context of a learning paradigm by giving tDCS over rIFG repetitively over four consecutive days of training on a behavioral inhibition task (stop signal task (SST)). Twenty-two participants took part; ten participants were assigned to receive anodal tDCS (1.5 mA, 15 min), 12 were assigned to receive training but not active stimulation. There was a significant effect of training on learning and performance in the SST, and the integration of the training and rIFG-tDCS produced a more linear learning slope. Better performance was also found in the active stimulation group. Our findings show that tDCS-combined cognitive training is an effective tool for improving the ability to inhibit responses. The current study could constitute a step toward the use of tDCS and cognitive training as a therapeutic tool for cognitive control impairments in conditions such as attention-deficit hyperactivity disorder (ADHD) or schizophrenia.