Deformation of articular cartilage during static loading of a knee joint - Experimental and finite element analysis
Deformation of articular cartilage during static loading of a knee joint - Experimental and finite element analysis
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DOI：
10.1016/j.jbiomech.2014.04.013
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发表时间：
2014-07-18
影响因子：
2.4
通讯作者：
Korhonen, R. K.
中科院分区：
文献类型：
--
作者：
Halonen, K. S.;Mononen, M. E.;Korhonen, R. K.
新型锥形束CT扫描仪提供高分辨率的膝关节结构与La的成像。造影剂，即使在负重情况下。利用这项新技术，我们的目的是确定软骨应变和人类膝关节在0，1，5，和30分钟的站立和比较，以受试者特定的三维有限元（FE）模型的运动。根据从磁共振图像获得的几何形状，创建志愿者膝关节的FE模型以模拟蠕变。研究了胶原纤维网络刚度、非纤维基质模量、渗透性和流体流动边界条件对软骨蠕变响应的影响。在实验中，软骨中80%的最大应变立即产生，之后软骨继续缓慢变形，直到30分钟时间点。从有限元模型获得的腕关节应变和弯月面运动与实验测量值充分匹配。降低原纤网络刚度的平均应变大幅增加，而蠕变速率主要是由非原纤基质模量的增加的影响。改变初始渗透性和防止流体流过非接触表面对软骨应变的影响可以忽略不计。本研究结果提高了对生理静态负荷下膝关节中控制关节软骨应变和关节运动的机制的理解。最终，经过验证的模型可以用作非侵入性诊断工具，以定位有退化风险的软骨区域。(C)2014爱思唯尔有限公司版权所有。
Novel conical beam CT-scanners offer high resolution imaging of knee structures with La. contrast media, even under weight bearing. With this new technology, we aimed to determine cartilage strains and meniscal movement in a human knee at 0,1, 5, and 30 min of standing and compare them to the subject-specific 3D finite element (FE) model. The FE model of the volunteer's knee, based on the geometry obtained from magnetic resonance images, was created to simulate the creep. The effects of collagen fibril network stiffness, nonfibrillar matrix modulus, permeability and fluid flow boundary conditions on the creep response in cartilage were investigated. In the experiment, 80% of the maximum strain in cartilage developed immediately, after which the cartilage continued to deform slowly until the 30 min time point. Cartilage strains and meniscus movement obtained from the FE model matched adequately with the experimentally measured values. Reducing the fibril network stiffness increased the mean strains substantially, while the creep rate was primarily influenced by an increase in the nonfibrillar matrix modulus. Changing the initial permeability and preventing fluid flow through noncontacting surfaces had a negligible effect on cartilage strains. The present results improve understanding of the mechanisms controlling articular cartilage strains and meniscal movements in a knee joint under physiological static loading. Ultimately a validated model could be used as a noninvasive diagnostic tool to locate cartilage areas at risk for degeneration. (C) 2014 Elsevier Ltd. All rights reserved.