The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.
The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.
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DOI：
10.1002/cphy.c210043
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发表时间：
2023-01-30
影响因子：
5.8
通讯作者：
中科院分区：
文献类型：
--
作者：
肾脏电解质和水分排泄异常可能导致不适当的盐分和水分滞留，从而促进高血压的发展和维持，以及酸碱和电解质紊乱。肾脏调节肾脏血流动力学和电解质排泄的一个关键机制是通过肾小管和小动脉之间的肾小管和小动脉之间的负反馈--肾小管球反馈。转化生长因子是由致密黄斑细胞的氯化钠递送增加引起的。升高的氯化钠激活致密斑细胞的腔Na-K-2Cl协转运体(NKCC2)，导致几个细胞内过程的激活，随后产生旁分泌信号，最终导致传入小动脉收缩和单肾单位肾小球滤过率的紧张性抑制。神经元一氧化氮合酶(NOS1)在致密斑区高表达。NOS1β是主要的剪接变异体，是致密黄斑产生的NO的主要来源，它抑制了转化生长因子的反应。致密黄斑β介导的转化生长因子反应的调节在钠排泄、容量和电解质止血以及血压的控制中起着至关重要的作用。在这篇文章中，我们描述了调节致密斑源性NO的机制及其在生理和病理条件下对转化生长因子反应的影响。
Abnormalities in renal electrolyte and water excretion may result in inappropriate salt and water retention, which facilitates the development and maintenance of hypertension, as well as acid-base and electrolyte disorders. A key mechanism by which the kidney regulates renal hemodynamics and electrolyte excretion is via tubuloglomerular feedback (TGF), an intrarenal negative feedback between tubules and arterioles. TGF is initiated by an increase of NaCl delivery at the macula densa cells. The increased NaCl activates luminal Na-K-2Cl cotransporter (NKCC2) of the macula densa cells, which leads to activation of several intracellular processes followed by production of paracrine signals that ultimately result in a constriction of the afferent arteriole and a tonic inhibition of single nephron glomerular filtration rate. Neuronal nitric oxide (NOS1) is highly expressed in the macula densa. NOS1β is the major splice variant and accounts for most of NO generation by the macula densa, which inhibits TGF response. Macula densa NOS1β-mediated modulation of TGF responses play an essential role in control of sodium excretion, volume and electrolyte hemostasis, and blood pressure. In this article, we describe the mechanisms that regulate macula densa-derived NO and their effect on TGF response in physiologic and pathologic conditions.
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影响因子：
19.6
作者：
Barri, YM;Wilcox, CS
通讯作者：
Wilcox, CS
DOI：
10.1152/ajprenal.1995.269.6.f793
发表时间：
1995-12-01
影响因子：
4.2
作者：
Bosse, HM;Bohm, R;Bachmann, S
通讯作者：
Bachmann, S
蛋白激酶A依赖性神经元一氧化氮合酶激活介导大鼠孤束核中肾上腺髓质素增强压力反射反应。
影响因子：
11
作者：
Yen DH;Chen LC;Shen YC;Chiu YC;Ho IC;Lou YJ;Chen IC;Yen JC
通讯作者：
Yen JC
影响因子：
9
作者：
BOUNOUS, G;SHUMACKER, HB
通讯作者：
SHUMACKER, HB
影响因子：
8.3
作者：
Brown, Russell D.;Hilliard, Lucinda M.;Denton, Kate M.
通讯作者：
Denton, Kate M.