The role of functional neuroimaging in the neuropsychology of depression
The role of functional neuroimaging in the neuropsychology of depression
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DOI：
10.1076/jcen.23.1.121.1223
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发表时间：
2001-02-01
影响因子：
2.2
通讯作者：
Mayberg, HS
中科院分区：
文献类型：
--
作者：
Liotti, M;Mayberg, HS
抑郁的人在注意力和集中力测试中表现出受损。他们还表现出PET静息状态异常的背侧前额叶皮层和前扣带回，已知的基板的注意力处理在健康个体的区域。本章概述了一个战略，研究神经心理机制，情绪障碍，使用功能成像方法。它回顾了强烈暗示背外侧前额叶皮层的证据，特别是在右半球，作为一个关键的大脑结构，在情绪/认知互动的负面情绪凝视。有人认为，这个新皮层区域是一个重要的会聚区，是持续关注外部环境的基底，也是健康和疾病状态变化期间边缘皮层影响的主要目标。
Depressed individuals show impaired performance in tests of attention and concentration. They also exhibit PET resting state abnormalities in dorsal prefrontal cortex and anterior cingulate, regions known to be substrates of attentional processing in healthy individuals. This chapter outlines a strategy to study neuropsychological mechanisms in emotional disorders using functional imaging methods. It reviews evidence strongly implicating the dorsolateral prefrontal cortex, particularly in the right hemisphere, as a key brain structure in emotion/cognition interactions in negative mood stares. It will be argued that this neocortical region is a crucial convergence zone, being the substrate of sustained attention to the external environment, and the main target of limbic-cortical influences during changes in mood state across health and disease.