Genetic diversity and Capillaria hepatica (Nematoda) prevalence in Michigan deer mouse populations
Genetic diversity and Capillaria hepatica (Nematoda) prevalence in Michigan deer mouse populations
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DOI：
10.1111/j.1558-5646.1999.tb04547.x
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发表时间：
1999-08-01
期刊：
影响因子：
3.3
通讯作者：
Meagher, S
中科院分区：
文献类型：
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作者：
Meagher, S
纯合子种群易患高水平疾病这一假说鲜有实地检验。我测试了遗传多样性和寄生之间的负相关，通过估计同工酶杂合性，种群密度，被毛线虫感染的个体比例在9个密歇根鹿鼠种群（Peromyscus maniculatus）。当密度效应保持不变时，寄生虫流行率与杂合度呈负相关，但在控制遗传多样性效应后，寄生虫流行率与种群密度不相关。这些数据支持了近亲繁殖的种群更容易受到寄生虫侵袭的预测。
There have been few field tests of the hypothesis that homozygous populations are prone to high levels of disease. I tested for a negative correlation between genetic diversity and parasitism by estimating the allozyme heterozygosity, population density, and proportion of individuals infected by Capillaria hepatica (Nematoda) in nine Michigan populations of deer mice (Peromyscus maniculatus). Parasite prevalence was correlated negatively with heterozygosity when the effects of density were held constant, but was not correlated with population density after controlling for the effects of genetic diversity. These data support the prediction that inbred populations will be more susceptible to parasite infestations.