Of mice and men: cancer gene discovery using comparative oncogenomics.
Of mice and men: cancer gene discovery using comparative oncogenomics.
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DOI：
10.1016/j.ccr.2006.06.013
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发表时间：
2006-07
期刊：
影响因子：
50.3
通讯作者：
S. Tomlins;A. Chinnaiyan
中科院分区：
文献类型：
--
作者：
S. Tomlins;A. Chinnaiyan
With the proliferation of high-throughput technologies to profile the cancer genome, methods to distinguish causal from bystander genetic events are needed. Two recent reports by Zender et al. and Kim et al. inCelluse genetically defined mouse models to serve as biological filters to mine the human cancer genome. Integration of high-resolution copy number profiles of mouse tumor models and human tumors identifiedcIAP1andYapas oncogenes in human hepatocellular carcinoma, whileNEDD9was identified as a metastasis gene in human melanoma. Together, these reports demonstrate that a comparative oncogenomics approach can identify genes causally involved in oncogenesis and metastasis.
