Evaluation and verification of patient-specific modelling of type B aortic dissection
Evaluation and verification of patient-specific modelling of type B aortic dissection
复制标题
B 型主动脉夹层患者特异性模型的评估和验证
DOI：
10.1016/j.compbiomed.2021.105053
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发表时间：
2021-11-27
影响因子：
7.7
通讯作者：
Xu, Xiao Yun
中科院分区：
文献类型：
--
作者：
Armour, Chloe H.;Guo, Baolei;Xu, Xiao Yun
通过计算流体动力学（CFD）模拟定量评估B型主动脉夹层（TBAD）复杂的血流动力学环境，可以提供详细的了解疾病及其进展。随着成像和计算技术的进步，已经开发了一些方法来提高CFD模拟的准确性和生理相关性。本研究提出了一种模拟TBAD血流的患者特定工作流程，利用CT图像、4D流MRI和侵入性多普勒导丝压力测量形式的最大量体内数据，在患者特定几何形状和边界条件方面实施推荐的当前最佳实践方法。该研究旨在通过对CFD和体内数据进行详细的定性和定量比较来评估和验证该工作流程。基于从5名TBAD患者获得的数据，获得了一系列基本模型输入，包括入口流量波形和3元件Windkessel模型参数，这些参数可用于体内流量数据不可用的进一步研究。局部和全局分析显示，CFD结果与4D-MRI数据之间具有良好的一致性，主要入口撕裂的最大速度差异高达0.3 m/s，80%的分析区域在预测速度与体内速度之间具有中度或较强的相关性。CFD预测的压力通常与多普勒导丝测量结果非常匹配，但收缩峰值存在一些偏差。总体而言，本研究提出了一个经过验证的全面工作流程，具有广泛的数据，用于TBAD的CFD模拟。
Quantitative assessment of the complex hemodynamic environment in type B aortic dissection (TBAD) through computational fluid dynamics (CFD) simulations can provide detailed insights into the disease and its progression. As imaging and computational technologies have advanced, methodologies have been developed to increase the accuracy and physiological relevance of CFD simulations. This study presents a patient-specific workflow to simulate blood flow in TBAD, utilising the maximum amount of in vivo data available in the form of CT images, 4D-flow MRI and invasive Doppler-wire pressure measurements, to implement the recommended current best practice methodologies in terms of patient-specific geometry and boundary conditions. The study aimed to evaluate and verify this workflow through detailed qualitative and quantitative comparisons of the CFD and in vivo data. Based on data acquired from five TBAD patients, a range of essential model inputs was obtained, including inlet flow waveforms and 3-element Windkessel model parameters, which can be utilised in further studies where in vivo flow data is not available. Local and global analysis showed good consistency between CFD results and 4D-MRI data, with the maximum velocity in the primary entry tear differing by up to 0.3 m/s, and 80% of the analysed regions achieving moderate or strong correlations between the predicted and in vivo velocities. CFD predicted pressures were generally well matched to the Doppler-wire measurements, with some deviation in peak systolic values. Overall, this study presents a validated comprehensive workflow with extensive data for CFD simulation of TBAD.