On the Molecular Bases of the Specificity of Interaction of Transcriptional Proteins with Genome DNA
On the Molecular Bases of the Specificity of Interaction of Transcriptional Proteins with Genome DNA
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转录蛋白与基因组DNA相互作用特异性的分子基础
DOI：
10.1007/978-1-4684-3417-0_8
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发表时间：
1979
影响因子：
14.9
通讯作者：
P. V. Hippel
中科院分区：
文献类型：
--
作者：
P. V. Hippel
为了了解基因组功能的转录控制，我们必须详细了解分子相互作用，转录蛋白通过分子相互作用识别基因组表面单调双螺旋 DNA 中存在的数百万个序列中的特定目标碱基对序列并与其相互作用。原核生物和真核生物中控制细胞功能和发育的大多数相互作用都涉及有序且渐进的 DNA-蛋白质相互作用。这些控制转录的相互作用的一部分被编程为产生所需的信使 RNA (mRNA) 分子，以适当的量和适当的稳定性，响应我们几乎一无所知的触发信号（除了一些特殊情况）。
In order to understand the transcriptional control of genome function, we must develop a detailed knowledge of the molecular interactions whereby transcriptional proteins recognize and interact with their specific target base pair sequences among the millions of sequences present in the superficially monotonic double-helical DNA of the genome. Most of the interactions that control cellular function and development in both prokaryotes and eukaryotes involve an orderly and progressive succession of DNA—protein interactions. The fraction of these interactions that control transcription are programmed to produce the required messenger RNA (mRNA) molecules, in proper amounts and with appropriate stabilities, in response to triggering signals about which we still know almost nothing (except in a few special cases).