Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis
Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis
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DOI：
10.1016/j.immuni.2014.05.016
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发表时间：
2014-07-17
期刊：
影响因子：
32.4
通讯作者：
Fagarasan, Sidonia
中科院分区：
文献类型：
--
作者：
Kawamoto, Shimpei;Maruya, Mikako;Fagarasan, Sidonia
Foxp3(+) T细胞对于维持免疫耐受起着至关重要的作用。在这里，我们表明，在小鼠中，Foxp3(+) T 细胞有助于肠道微生物群的多样化，特别是属于厚壁菌门的物种。 Foxp3(+) T细胞对本土细菌的控制涉及生发中心(GC)外部和内部的调节功能，分别包括抑制炎症和调节派尔氏集结中的免疫球蛋白A (IgA)选择。多样化和选择性的 IgAs 有助于维持多样化和平衡的微生物群，进而通过共生调节环促进 Foxp3(+) T 细胞的扩增、GC 的诱导和肠道中的 IgA 反应。因此，适应性免疫系统通过免疫耐受所需的细胞和分子成分以及抗体库的多样化和选择，通过控制体内平衡所需的细菌群落的丰富度和平衡来介导宿主-微生物共生。
Foxp3(+) T cells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3(+) T cells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes. The control of indigenous bacteria by Foxp3(+) T cells involved regulatory functions both outside and inside germinal centers (GCs), consisting of suppression of inflammation and regulation of immunoglobulin A (IgA) selection in Peyer's patches, respectively. Diversified and selected IgAs contributed to maintenance of diversified and balanced microbiota, which in turn facilitated the expansion of Foxp3(+) T cells, induction of GCs, and IgA responses in the gut through a symbiotic regulatory loop. Thus, the adaptive immune system, through cellular and molecular components that are required for immune tolerance and through the diversification as well as selection of antibody repertoire, mediates host-microbial symbiosis by controlling the richness and balance of bacterial communities required for homeostasis.