Tracing from the dorsal premammillary nucleus prosencephalic systems involved in the organization of innate fear responses
Tracing from the dorsal premammillary nucleus prosencephalic systems involved in the organization of innate fear responses
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DOI：
10.1016/s0149-7634(01)00048-3
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发表时间：
2001-12-01
影响因子：
8.2
通讯作者：
Comoli, E
中科院分区：
文献类型：
--
作者：
Canteras, NS;Ribeiro-Barbosa, ÉR;Comoli, E
背侧乳头体前核（PMd）被认为在对环境威胁的恐惧反应表达中起关键作用。我们先前曾报道，在遭遇捕食者时，PMd的Fos水平显著升高，而其中特定细胞体的化学损伤几乎消除了逃跑和僵直反应的表达。因此，PMd可被视为描绘对先天恐惧反应的组织似乎至关重要的前脑回路的一个关键起点。在本综述中，我们全面考察了可能参与影响这一下丘脑部位的神经回路，并以我们实验室最近对暴露于活捕食者的大鼠中枢神经系统中Fos蛋白表达的观察结果对这一分析进行补充。（C）2002爱思唯尔科学有限公司。保留所有权利。
The dorsal premammillary nucleus (PMd) is thought to play a critical role in the expression of fear responses to environmental threats. We have previously reported that, during an encounter with a predator, the PMd presents an impressive increase in Fos levels and cell body-specific chemical lesions therein virtually eliminated the expression of escape and freezing responses. Therefore, the PMd may be viewed as a strategic starting point to delineate prosencephalic circuits seemingly critical for the organization of innate fear responses. In the present review, we provide a comprehensive examination of the neural circuits putatively involved in influencing this hypothalamic site, and supplement this analysis with recent observations from our laboratory on the expression of Fos protein in the central nervous system of rats exposed to a live predator. (C) 2002 Elsevier Science Ltd. All rights reserved.