Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels
Two-dimensional simulation of red blood cell deformation and lateral migration in microvessels
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DOI：
10.1007/s10439-007-9275-0
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发表时间：
2007-05-01
影响因子：
3.8
通讯作者：
Pries, Axel R.
中科院分区：
文献类型：
--
作者：
Secomb, Timothy W.;Styp-Rekowska, Beata;Pries, Axel R.
基于对哺乳动物红细胞力学特性的认识，采用理论方法模拟了红细胞在微血管中的运动和变形。每个红细胞表示为一组相互连接的粘弹性元素在两个维度。使用有限元数值方法计算细胞的运动和变形以及周围流体的运动。在高粘度流体的简单剪切流中的RBC运动的模拟显示了如实验所观察到的细胞周边的膜的“坦克-包围”运动。适当选择的参数代表RBC的机械性能，坦克踩踏频率和细胞伸长率同意密切与观察剪切速率的范围内。在模拟红细胞在毛细血管大小的通道中的运动时，最初的圆形细胞形状迅速接近在毛细血管中实验观察到的典型形状，前凸后凹。进入8 μ m毛细血管壁附近的分离的RBC预计在横向方向上迁移，因为它穿过毛细血管，在行进约60 μ m的距离后达到中心线附近的位置。细胞轨迹与大鼠肠系膜微血管中观察到的密切一致。
A theoretical method is used to simulate the motion and deformation of mammalian red blood cells (RBCs) in microvessels, based on knowledge of the mechanical characteristics of RBCs. Each RBC is represented as a set of interconnected viscoelastic elements in two dimensions. The motion and deformation of the cell and the motion of the surrounding fluid are computed using a finite-element numerical method. Simulations of RBC motion in simple shear flow of a high-viscosity fluid show "tank-treading'' motion of the membrane around the cell perimeter, as observed experimentally. With appropriate choice of the parameters representing RBC mechanical properties, the tank-treading frequency and cell elongation agree closely with observations over a range of shear rates. In simulations of RBC motion in capillary-sized channels, initially circular cell shapes rapidly approach shapes typical of those seen experimentally in capillaries, convex in front and concave at the rear. An isolated RBC entering an 8-mu m capillary close to the wall is predicted to migrate in the lateral direction as it traverses the capillary, achieving a position near the center-line after traveling a distance of about 60 mu m. Cell trajectories agree closely with those observed in microvessels of the rat mesentery.