Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats.
Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats.
复制标题
心房钠尿肽可减轻油酸诱导的大鼠急性肺损伤模型的炎症反应。
DOI：
10.3760/cma.j.issn.0366-6999.20122435
复制
发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Liu, Ying-long
中科院分区：
文献类型：
--
作者：
Zhu, Yao-bin;Zhang, Yan-bo;Liu, Dong-hai;Li, Xiao-feng;Liu, Ai-jun;Fan, Xiang-ming;Qiao, Chen-hui;Ling, Feng;Liu, Ying-long
BACKGROUND
An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities, including effects on endothelial function and inflammation. A recent study has revealed that ANP exerts anti-inflammatory effects. In this study we tested the effects of human ANP (hANP) on lung injury in a model of oleic acid (OA)-induced acute lung injury (ALI) in rats.
METHODS
Rats were randomly assigned to three groups (n = 6 in each group). Rats in the control group received a 0.9% solution of NaCl (1 ml × kg(-1) × h(-1)) by continuous intravenous infusion, after 30 minutes a 0.9% solution of NaCl (1 ml/kg) was injected intravenously, and then the 0.9% NaCl infusion was restarted. Rats in the ALI group received a 0.9% NaCl solution (1 ml × kg(-1) × h(-1)) intravenous infusion, after 30 minutes OA was injected intravenously (0.1 ml/kg), and then the 0.9% NaCl infusion was restarted. Rats in the hANP-treated ALI group received a hANP (0.1 µg × kg(-1) × min(-1)) infusion, after 30 minutes OA was injected intravenously (0.1 ml/kg), and then the hANP infusion was restarted. The anti-inflammation effects of hANP were evaluated by histological examination and determination of serum cytokine levels.
RESULTS
Serum interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor (TNF) α were increased in the ALI group at six hours. The levels of all factors were significantly lower in the hANP treated rats (P < 0.005). Similarly, levels of IL-1β, IL-6, IL-10 and TNF-α were higher in the lung tissue in the ALI group at six hours. hANP treatment significantly reduced the levels of these factors in the lungs (P < 0.005). Histological examination revealed marked reduction in interstitial congestion, edema, and inflammation.
CONCLUSION
hANP can attenuate inflammation in an OA-induced lung injury in rat model.
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间充质干细胞的静脉移植可减轻油酸诱导的大鼠急性肺损伤。
DOI：
--
发表时间：
2012
期刊：
中华医学杂志(英文版)
影响因子：
--
作者：
Xu, Yu-Lin;Liu, Ying-Long;Wang, Qiang;Li, Gang;Lu, Xiao-Dong;Kong, Bo
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Kong, Bo
DOI：
10.1152/ajplung.00202.2009
发表时间：
2010-11-01
影响因子：
4.9
作者：
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通讯作者：
Birukov, Konstantin G.
影响因子：
6.1
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Yao-bin Zhu;Xiangming Fan;Xiao-feng Li;Zhiqiang Li;Qiang Wang;Li-Zhong Sun;Yinglong Liu
通讯作者：
Yao-bin Zhu;Xiangming Fan;Xiao-feng Li;Zhiqiang Li;Qiang Wang;Li-Zhong Sun;Yinglong Liu
影响因子：
6.1
作者：
Yao-bin Zhu;Feng Ling;Yan-bo Zhang;Ai-Jun Liu;Dong-hai Liu;C. Qiao;Qiang Wang;Yinglong Liu
通讯作者：
Yao-bin Zhu;Feng Ling;Yan-bo Zhang;Ai-Jun Liu;Dong-hai Liu;C. Qiao;Qiang Wang;Yinglong Liu
影响因子：
6.1
作者：
Yao-bin Zhu;Qiang Wang;Yinglong Liu;Xiao-feng Li;Jian-an Li;X. Lü;Feng Ling;Ai-Jun Liu;Xiangming Fan
通讯作者：
Yao-bin Zhu;Qiang Wang;Yinglong Liu;Xiao-feng Li;Jian-an Li;X. Lü;Feng Ling;Ai-Jun Liu;Xiangming Fan