Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves.
Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves.
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DOI：
10.1177/2150135113501901
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发表时间：
2013-10
影响因子：
0.9
通讯作者：
Nigam V
中科院分区：
文献类型：
--
作者：
Szeto K;Pastuszko P;del Álamo JC;Lasheras J;Nigam V
目的：确定与三尖瓣(TAV)瓣叶相比，二尖瓣(BAV)瓣叶是否承受更大的张力。主动脉瓣钙化(AVC)风险最高的人群是患有BAVs的个体。目前，由于对AVC分子发病机制中涉及的生物力学因素的了解有限，AVC的医学治疗努力受到阻碍。手术创建的BAVs和对照TAVs被放置在左心模拟器中。在模拟心动周期的不同时间点，通过比较主动脉瓣(AOV)叶上各点之间的距离来计算应变。与TAVs相比，BAVs的融合叶在收缩时承受更大的张力。具体地说，与TAVs相比，BAVs在与血流方向平行的径向上经历24%的应变(P<；.0001)。周向最大差值为4%(P<；.001)。基于这里提供的数据，我们正在确定应变增加如何激活AOV细胞中的钙化相关途径。未来的研究将检查这些伸展反应通路是否可以被阻断以抑制BAVs的钙化。
To determine whether the leaflets of bicuspid aortic valve (BAV) experience increased strain when compared to tricuspid aortic valve (TAV) leaflets. The population at highest risk of aortic valve calcification (AVC) are individuals with BAVs. Currently, efforts to medically treat AVC are hampered by a limited understanding of the biomechanical forces involved in the molecular pathogenesis of AVC. Surgically created BAVs and control TAVs were placed into a left heart simulator. Strains were calculated by comparing the distances between points on the aortic valve (AoV) leaflet during various time points during a simulated cardiac cycle. The fused leaflets of BAVs experience significantly more strain during systole when compared to TAVs. Specifically, BAVs experience 24% strain (P < .0001) in the radial direction, parallel to the direction of blood flow, as compared to TAVs. There was peak difference of 4% (P < .001) in the circumferential direction. Based upon the data presented here, we are in the process of identifying how increased strain activates calcification-associated pathways in AoV cells. Future studies will examine whether these stretch responsive pathways can be blocked to inhibit calcification of BAVs.