Selection of optimal wavelengths for spectral reconstruction in diffuse optical tomography
Selection of optimal wavelengths for spectral reconstruction in diffuse optical tomography
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DOI：
10.1117/1.3156823
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发表时间：
2009-05-01
影响因子：
3.5
通讯作者：
Nielsen, Tim
中科院分区：
文献类型：
--
作者：
Brendel, Bernhard;Nielsen, Tim
在扩散光学层析成像（光谱DOT）中使用具有不同波长的激光具有可以定量重建发色团浓度的优点。在连续波谱DOT中，还可以区分散射和吸收。激光波长的选择对散射参数和发色团浓度的确定有很大影响。目前的方法，以优化的波长组忽略了灵敏度的重建结果的不确定性的吸收光谱的发色团。但是，由于现有的吸收光谱显示出显着的偏差，似乎有必要考虑到这一点。这里提出的波长优化方法是Corlu等人的方法的扩展。原始方法优化了波长组，使得散射参数和发色团浓度可以最佳地分离。我们引入了一个额外的标准，评估重建的生色团浓度的消光系数偏差的依赖。新方法得到的波长组与原方法得到的波长组不同。模拟数据的重建显示了使用不同的吸收光谱与不同的波长组重建的效果，并说明了新的波长组的优点。(C)2009年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。[DOI 10.1117/1.3156823]
Using lasers with different wavelengths in diffuse optical tomography (spectral DOT) has the advantage that the concentrations of chromophores can be reconstructed quantitatively. In continuous wave spectral DOT, it is furthermore possible to distinguish between scattering and absorption. The choice of the laser wavelengths has a strong impact on how well the scattering parameter and chromophore concentrations can be determined. Current methods to optimize the set of wavelengths disregard the sensitivity of the reconstruction result to uncertainties in the absorption spectra of the chromophores. But since available absorption spectra show significant deviations, it seems to be necessary to take this into account. The wavelength optimization approach presented here is an extension to a method of Corlu et al. The original method optimizes the wavelength sets such that scattering parameters and chromophore concentrations can be separated optimally. We introduce an additional criterion that evaluates the dependence of reconstructed chromophore concentrations on deviations of the extinction coefficients. The wavelength sets found by the new approach are different from those determined with the original method. Reconstructions of simulated data show the effect of using various absorption spectra for reconstruction with different wavelength sets and illustrate the advantages of the new wavelength sets. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3156823]