Subchronic 90-day oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs
Subchronic 90-day oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs
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DOI：
10.1016/j.fct.2006.07.023
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发表时间：
2006-12-01
影响因子：
4.3
通讯作者：
Heimbach, J.
中科院分区：
文献类型：
--
作者：
Qin, X.;Xiaojian, S.;Heimbach, J.
在雄性和雌性狗中进行了一项28天和90天的联合口服（灌胃）研究，以研究PureLo（R）的安全性，PureLo（R）是一种来自中国水果罗汉果的无热量甜味剂，其甜味来自三萜糖苷（称为罗汉果苷）的存在。对每种性别的三只犬给予10 mL/kg bw/天的水溶液（提供3000 mg/kg bw/天的PureLo（（R）或蒸馏水，持续28天或90天。测量包括临床观察、体重、摄食量、血液学、血液化学、尿分析、大体尸检、器官重量和组织病理学。这些措施均无显著不良影响。基于研究中缺乏毒理学效应，当连续90天灌胃给予犬时，PureLo（（R））的NOAEL为3000 mg/kg bw/天。(c)2006爱思唯尔有限公司保留所有权利。
A combined 28-day and 90-day oral (Gavage) study was conducted in male and female dogs to investigate the safety of PureLo((R)), a non-caloric sweetener derived from the Chinese fruit Luo Han Guo, which achieves its sweetness from the presence of triterpene glycosides known as mogrosides. Three dogs of each sex were administered 10 mL/kg bw/day of either an aqueous solution providing 3000 mg/kg bw/day of PureLo((R)) or distilled water for either 28 days or 90 days. Measurements included clinical observations, body weight, food consumption, hematology, blood chemistry, urinalysis, gross necropsy, organ weight, and histopathology. There were no significant adverse effects on any of these measures. Based on the lack of toxicological effects in the study, the NOAEL for PureLo((R)) is 3000 mg/kg bw/day when administered to dogs by Gavage for 90 consecutive days. (c) 2006 Elsevier Ltd. All rights reserved.