MUCINOUS COLORECTAL-CARCINOMA - IMMUNOPATHOLOGY AND PROGNOSIS
MUCINOUS COLORECTAL-CARCINOMA - IMMUNOPATHOLOGY AND PROGNOSIS
复制标题
DOI：
10.3109/00313028009077107
复制
发表时间：
1980-01-01
期刊：
影响因子：
4.5
通讯作者：
ROLLO, AJ
中科院分区：
文献类型：
--
作者：
PIHL, E;NAIRN, RC;ROLLO, AJ
共519人结直肠癌进行了检查的存在或不存在的粘液分化的显微镜形态测定法。其中，28%有客观可测量量的粘液性肿瘤上皮。在A期和C期，粘液区> 50%的肿瘤（14%）的预后明显差于非粘液区，而在B期和D期，粘液分化与预后无关。粘液性肿瘤区域的淋巴结具有显著较少的副皮质反应，而粘液分化> 50%的淋巴结在肿瘤边缘的血管周围淋巴细胞袖口显著较少。这些淋巴结和间质区是假定的T淋巴细胞区域。粘液性肿瘤显然对细胞介导的免疫力的刺激性较小，或者可能是抑制性较小。
A total of 519 [human] colorectal carcinomas were examined for the presence or absence of mucinous differentiation by means of microscopical morphometry. Of these, 28% had objectively measurable amounts of mucinous tumour epithelium. Tumors with > 50% mucinous areas (14%) had significantly poorer prognosis than nonmucinous in stages A and C, while mucinous differentiation did not correlate with prognosis in stages B and D. Lymph nodes regional to mucinous tumors had significantly less paracortical response, and those with > 50% mucinous differentiation, significantly less perivascular lymphocyte cuffing at the tumor margins. These lymph node and stromal compartments are putative T-lymphocyte areas. Mucinous tumours apparently are less stimulatory or perhaps inhibitory of cell-mediated immunity.