Type IV collagens and Dpp Positive and negative regulators of signaling
Type IV collagens and Dpp Positive and negative regulators of signaling
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DOI：
10.4161/fly.7463
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发表时间：
2008-11-01
期刊：
影响因子：
1.2
通讯作者：
Ashe, Hilary L.
中科院分区：
文献类型：
--
作者：
Ashe, Hilary L.
Decapentaplegic（Dpp）是TGF β/BMP超家族中的一种重要形态发生蛋白，在果蝇发育的多个阶段（包括卵巢和胚胎）中形成细胞场。我们已经发现，IV型胶原蛋白结合到Dpp和调节其信号在这两个发育阶段。本文主要集中在IV型胶原和胚胎Dpp信号方面的IV型胶原突变体表型的背景下，从该领域的其他数据进行讨论。此外，Dpp信号在卵巢中的IV型胶原蛋白的限制进行了描述，因为胚胎和卵巢Dpp源之间的差异导致在两个系统中的IV型胶原蛋白的不同效果。
Decapentaplegic (Dpp) is an essential morphogen in the TGF beta/BMP superfamily, which patterns fields of cells during multiple stages of Drosophila development, including the ovary and embryo. We have found that type IV collagens bind to Dpp and regulate its signaling during these two developmental stages. This article primarily focuses on type IV collagens and embryonic Dpp signaling to discuss aspects of the type IV collagen mutant phenotype in the context of additional data from the field. In addition, the restriction of Dpp signaling in the ovary by type IV collagens is described, as the differences between the embryonic and ovarian Dpp sources result in distinct effects of collagen IV proteins in the two systems.