Three-dimensional analysis of linear vestibulo-ocular reflex in humans during eccentric rotation while facing downwards
Three-dimensional analysis of linear vestibulo-ocular reflex in humans during eccentric rotation while facing downwards
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DOI：
10.1007/s00221-017-4990-8
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发表时间：
2017-08-01
影响因子：
2
通讯作者：
Inohara, Hidenori
中科院分区：
文献类型：
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作者：
Imai, Takao;Takimoto, Yasumitsu;Inohara, Hidenori
当参与者经历偏心旋转（ER）时，即，当它们从旋转轴移位时旋转，它们经历旋转刺激和线性加速度，这引起角前庭眼反射（aVOR）和线性VOR（IVOR）。在ER期间，由切向线加速度引起的IVOR增强由aVOR引起的眼球运动。在这项研究中，我们试图分别测量aVOR和lVOR，而参与者在暗室中面朝地面接受ER。我们分析了三维眼球运动使用视频眼电系统。参与者坐在旋转中心正上方的急诊室椅子上，或者他们的头向外，头向内，右耳向外，左耳向外靠着旋转中心。在这些条件下，对于旋转刺激（aVOR），眼睛的旋转轴垂直于地面，并且对于线性刺激（IVOR），该轴平行于地面。因此，测量的眼球运动可以分为这两个分量。在0.1和0.3 Hz旋转时，我们观察到aVOR而不是lVOR。然而，当刺激频率高于0.5Hz时，我们观察到aVOR和lVOR。这些数据表明，当刺激频率高于0.5 Hz时，IVOR被激活。我们得出结论，这是可能的，分别分析aVOR和lVOR，并同时评估aVOR和lVOR的功能，通过分析眼运动时，参与者经历ER高于0.5 Hz，而面向地面。
When participants undergo eccentric rotation (ER), i.e., they are rotated while displaced from the axis of rotation, they undergo both rotational stimulation and linear acceleration, which induces both the angular vestibulo-ocular reflex (aVOR) and linear VOR (lVOR). During ER, the lVOR induced by tangential linear acceleration enhances the eye movement induced by aVOR. In this study, we attempted to measure aVOR and lVOR separately, while participants underwent ER while facing the ground in a dark room. We analyzed three-dimensional eye movements using a video-oculography system. The participants sat on the ER chair either directly above the center of rotation, or with their head out, head in, right ear out, or left ear out against the center of rotation. Under these conditions, the rotational axis of the eye was perpendicular to the ground for rotational stimulation (aVOR), and the axis was parallel to the ground for linear stimulation (lVOR). Thus, measured eye movements could be separated into these two components. At 0.1 and 0.3 Hz rotation, we observed aVOR but not lVOR. However, when the stimulation frequency was above 0.5 Hz, we observed both aVOR and lVOR. These data indicate that lVOR is activated when the stimulation frequency is above 0.5 Hz. We conclude that it is possible to separately analyze aVOR and lVOR, and to simultaneously assess the function of aVOR and lVOR by analyzing eye movements induced when participants undergo ER above 0.5 Hz while facing the ground.