Lipid Bound Sialic Acid in Cancer Patients
Lipid Bound Sialic Acid in Cancer Patients
复制标题
癌症患者中的脂质结合唾液酸
DOI：
10.1177/030089168507100207
复制
发表时间：
1985
期刊：
影响因子：
1.9
通讯作者：
G. Ceriotti
中科院分区：
文献类型：
--
作者：
L. Salvagno;E. Ferrazzí;V. C. Sileni;S. Maggi;F. Tredese;Claudia Bedendo;Michela Paola Russo;M. Fiorentino;G. Ceriotti
用最近描述的方法测定了108例健康受试者和138例各种实体瘤和恶性血液病患者的血清脂质结合唾液酸（LSA）。在血清采样时，128例患者患有活动性疾病，10例患者没有疾病证据。128例活动性疾病患者中104例（81.2%）LSA升高，而74例癌胚抗原仅21例（28.4%）升高（P < 0.05）。血清LSA测试的敏感性范围从乳腺癌和胃肠道癌的66%到肺癌的92%。在肺癌、卵巢癌或霍奇金病患者中，LSA与疾病的程度相关，并且它也被证明是有用的。我们的初步数据表明，该测试可用作肿瘤负荷的监测。
Serum lipid-bound sialic acid (LSA) was measured with a recently described procedure in 108 healthy subjects and in 138 patients with a variety of solid tumors and hematologic malignancies. At the time of serum sampling, 128 patients had active disease and 10 patients had no evidence of disease. LSA was elevated in 104 of 128 (81.2%) patients with active disease, while carcinoembryonic antigen, analyzed in 74, was elevated only in 21 (28.4%) (P < 0.05). Sensitivity of the serum LSA test ranged from 66% for breast and gastrointestinal cancer to 92% for lung cancer. In patients with lung cancer, ovarian cancer or Hodgkin's disease, LSA was correlated with the extent of disease and it also proved to be useful in following the course of disease. Our preliminary data indicate that this test can be used as a monitor of tumor burden.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
测定血浆或血清中脂质结合唾液酸的改进方法。
DOI：
--
发表时间：
1980
期刊：
Research communications in chemical pathology and pharmacology
影响因子：
--
作者：
Katopodis,N;Stock,CC
通讯作者：
Stock,CC