Transcription regulation within the circadian clock: The E-box and beyond
Transcription regulation within the circadian clock: The E-box and beyond
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DOI：
10.1177/0748730404268052
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发表时间：
2004-10-01
影响因子：
3.5
通讯作者：
Hardin, PE
中科院分区：
文献类型：
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作者：
Hardin, PE
昼夜节律振荡器由从蓝藻到人类的生物体的转录反馈回路组成。这些转录反馈回路之所以如此命名，是因为转录调节因子积累到很高的水平，然后反馈控制自己基因的转录，从而在基因表达中产生自我维持的节奏。在昆虫和脊椎动物中，编码这些反馈调节因子的基因非常保守，其功能不是控制1个，而是控制2个反馈回路。这些反馈回路在昼夜节律周期的相反阶段控制有节奏的转录，但它们是连锁的，因为它们共享许多组成部分。在这篇综述中，作者将比较果蝇和哺乳动物反馈回路中的转录调控机制，并概述关于这些反馈回路内部和下游转录调控的剩余问题。
The circadian oscillator is composed of transcriptional feedback loops in organisms ranging from cyanobacteria to humans. These transcriptional feedback loops are so named because transcriptional regulators accumulate to high levels and then feed back to control their own genes' transcription, thus generating a self-sustaining rhythm in gene expression. In insects and vertebrates, the genes that encode these feedback regulators are remarkably well conserved and function to control not 1 but 2 feedback loops. These feedback loops control rhythmic transcription in opposite phases of the circadian cycle, yet they are interlocked because they share a number of components. In this review, the author will compare transcriptional regulatory mechanisms within the Drosophila and mammalian feedback loops and outline remaining questions concerning transcriptional regulation within and downstream of these feedback loops.