Spleen size determined by ultrasound in patients with sickle cell trait, HbAC trait and glucose-6-phosphate-dehydrogenase deficiency in a malaria hyperendemic area (Ashanti Region, Ghana)
Spleen size determined by ultrasound in patients with sickle cell trait, HbAC trait and glucose-6-phosphate-dehydrogenase deficiency in a malaria hyperendemic area (Ashanti Region, Ghana)
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DOI：
10.1016/s0001-706x(01)00157-7
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发表时间：
2001-10-22
期刊：
影响因子：
2.7
通讯作者：
Meyer, CG
中科院分区：
文献类型：
--
作者：
Burchard, GD;Browne, ENL;Meyer, CG
在横断面调查中，脾脏肿大的发生率及其年龄分布长期以来一直被用作估计疟疾流行的粗略措施。然而，脾脏大小受几个变量的影响，如果在研究人群中观察到这些变量，则应考虑这些变量。我们假设脾脏指数依赖于不同的红细胞多态性。因此，我们预计镰状细胞性状（HbAS），HbAC性状和GOD缺乏症患者的脾肿大的患病率低于无红细胞疾病的患者，可能是由于这些人的疟疾发作的发病率较低。然而，在我们的调查中，HbAA、HbAS和HbAC阳性个体之间的脾脏率和大小没有显著差异。此外，在有和没有葡萄糖-6-磷酸脱氢酶（G6 PD）缺乏（G6 PD-A（-））的人中，脾脏肿大的频率相似。(C)2001 Elsevier Science B. V.保留所有权利。
The occurrence of enlarged spleens and its age distribution has long been used as a crude measure to estimate malaria endemicity in cross-sectional surveys. Spleen size, however, is influenced by several variables that should be considered if they are observed in a population under study. We hypothesized that spleen indices are dependent on distinct red blood cell polymorphisms. Accordingly, we expected a lower prevalence of splenomegaly among patients with the sickle-cell trait (HbAS), HbAC trait and GOD deficiency than in patients without red cell disorders, possibly due to the lower incidence of malaria attacks in these individuals. In our survey, however, spleen rates and sizes did not differ significantly between HbAA-, HbAS- and HbAC-positive individuals. Furthermore, enlargement of spleens was found at similar frequencies in persons with and without glucose-6-phosphate-dehydrogenase (G6PD)-deficiency (G6PD-A(-)). (C) 2001 Elsevier Science B.V. All rights reserved.