EXISTENCE OF GLUTAMATE IN NORADRENERGIC LOCUS-COERULEUS NEURONS OF RODENTS
EXISTENCE OF GLUTAMATE IN NORADRENERGIC LOCUS-COERULEUS NEURONS OF RODENTS
复制标题
DOI：
10.1016/0361-9230(94)90164-3
复制
发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
BARNES, CD
中科院分区：
文献类型：
--
作者：
FUNG, SJ;REDDY, VK;BARNES, CD
本研究区分了三种类型的免疫标记神经元在蓝斑核（LC）的大鼠和小鼠：细胞的酪氨酸羟化酶样免疫反应性（TH-LI）或谷氨酸（Glu）-LI的单标记，和那些双标记的抗原。虽然双标记神经元往往位于大鼠LC核的中间和腹侧的三分之一，在其整个吻尾向范围，这种功能在小鼠中不明显。在大鼠和小鼠LC中，TH-和Glu-阳性神经元的数量最多，分别为62%和77%。利用相结合的逆行和免疫组织化学标记的其他研究表明，这种高发病率的共存TH-和谷氨酸-LI也代表了大鼠的蓝斑皮质神经元（69%和75%的所有同侧和对侧的投射细胞，分别）。讨论了蓝斑皮质神经元参与谷氨酸和去甲肾上腺素介导的靶神经元功能障碍的可能作用。
This study distinguished three types of immunolabeled neurons in nucleus locus coeruleus (LC) of the rat and mouse: cells single labeled either for tyrosine hydroxylase-like immunoreactivity (TH-LI) or glutamate (Glu)-LI, and those double labeled for both antigens. Although the double labeled neurons tend to be located in the middle and ventral thirds of the rat LC nucleus, throughout its rostrocaudal extent, such feature was not apparent in the mouse. Quantitatively a majority of neurons cocontaining TH- and Glu-LI were commonly observed in the rat (62%) and mouse (77%) LC. Additional studies utilizing the combined retrograde and immunohistochemical labeling revealed that such a high incidence of coexistence of the TH- and Glu-LI was also represented by coeruleocortical neurons in the rat (69% and 75% of all ipsilateral and contralateral projection cells, respectively). A possible role of coeruleocortical neurons involvement in Glu- and norepinephrine-mediated target neuron dysfunction is discussed.