Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development
Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development
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DOI：
10.1101/gad.13.15.1918
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发表时间：
1999-08-01
影响因子：
10.5
通讯作者：
Leder, P
中科院分区：
文献类型：
--
作者：
Michaelson, JS;Bader, D;Leder, P
The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Darn in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown. To elucidate the in vivo role of Daxx, we have generated Daxx-deficient mice. Surprisingly, rather than a hyperproliferative disorder expected from the loss of a pro-apoptotic gene, mutation of Daxx results in extensive apoptosis and embryonic lethality. These findings argue against a role for Daxx in promoting Fas-induced cell death and suggest that Daxx either directly or indirectly suppresses apoptosis in the early embryo.
