WoLF PSORT: protein localization predictor.
WoLF PSORT: protein localization predictor.
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Wolf Psort：蛋白质定位预测因子。
DOI：
10.1093/nar/gkm259
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发表时间：
2007-07
影响因子：
14.9
通讯作者：
Nakai, Kenta
中科院分区：
文献类型：
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作者：
Horton, Paul;Park, Keun-Joon;Obayashi, Takeshi;Fujita, Naoya;Harada, Hajime;Adams-Collier, C J;Nakai, Kenta
WoLF PSORT是用于蛋白质亚细胞定位预测的PSORT II程序的扩展。WoLF PSORT将蛋白质氨基酸序列转换为数值定位特征；基于分选信号、氨基酸组成以及诸如DNA结合基序等功能基序。转换之后，使用一个简单的k - 近邻分类器进行预测。通过html，每种预测的证据以两种方式展示：(i) 具有与查询序列最相似定位特征的已知定位蛋白质列表，以及(ii) 包含单个定位特征详细信息的表格。为方便起见，提供了查询序列与相似蛋白质的序列比对以及指向UniProt和基因本体论的链接。综上所述，这些信息使用户能够了解对特定蛋白质所做预测背后的证据（或缺乏证据的情况）。WoLF PSORT可在wolfpsort.org获取。
WoLF PSORT is an extension of the PSORT II program for protein subcellular location prediction. WoLF PSORT converts protein amino acid sequences into numerical localization features; based on sorting signals, amino acid composition and functional motifs such as DNA-binding motifs. After conversion, a simple k-nearest neighbor classifier is used for prediction. Using html, the evidence for each prediction is shown in two ways: (i) a list of proteins of known localization with the most similar localization features to the query, and (ii) tables with detailed information about individual localization features. For convenience, sequence alignments of the query to similar proteins and links to UniProt and Gene Ontology are provided. Taken together, this information allows a user to understand the evidence (or lack thereof) behind the predictions made for particular proteins. WoLF PSORT is available at wolfpsort.org