Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection.
Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection.
复制标题
对单纯疱疹病毒 1 (HSV-1) 感染的免疫抵抗机制。
DOI：
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发表时间：
1976
影响因子：
4.4
通讯作者：
Anthony C. Allison
中科院分区：
文献类型：
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作者：
Bracha Rager;Anthony C. Allison
成年小鼠对ip.单次注射环磷酰胺可显著增加HSV-1的感染。经环磷酰胺治疗的病毒感染小鼠的死亡率与病毒复制增加以及脑和肝脏的病理变化有关。在特定的免疫脾细胞转移后，免疫抑制小鼠的致命性感染的发展可以被抑制。被动转移抗体则无此作用。经抗theta血清处理后，脾细胞的保护活性明显降低。同时给予正常脾细胞和免疫血清也可获得明显的保护作用。我们的结果表明，对这种病毒感染的保护主要依赖于T细胞，并表明抗体依赖的细胞介导的保护也可能在体内起作用。
Susceptibility of adult mice to i.p. infection with HSV-1 was greatly increased by administration of a single dose of cyclophosphamide. Mortality of cyclophosphamide-treated virus-infected mice was associated with increased virus replication and pathologic changes in brain and liver. The development of a fatal infection in immunosuppressed mice could be curtailed after transfer of specifically immune spleen cells. Passively transferred antibody had no such effect. Protective activity of spleen cells was significantly reduced after pretreatment with anti-theta serum. Significant protection was also achieved when normal spleen cells plus immune serum were administered simultaneously. Our results indicate that protection against this virus infection is predominantly T cell dependent, and suggests that antibody-dependent cell-mediated protection may also be operative in vivo.