CB-1954 (2,4-DINITRO-5-AZIRIDINYL BENZAMIDE) BECOMES A DNA INTERSTRAND CROSS-LINKING AGENT IN WALKER TUMOR-CELLS
CB-1954 (2,4-DINITRO-5-AZIRIDINYL BENZAMIDE) BECOMES A DNA INTERSTRAND CROSS-LINKING AGENT IN WALKER TUMOR-CELLS
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DOI：
10.1016/0006-291x(86)90744-8
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发表时间：
1986-11-14
影响因子：
3.1
通讯作者：
KNOX, RJ
中科院分区：
文献类型：
--
作者：
ROBERTS, JJ;FRIEDLOS, F;KNOX, RJ
与其他体外细胞相比，沃克肿瘤细胞对CB 1954具有独特的敏感。 CB 1954在沃克肿瘤中以时间依赖的方式形成DNA-DNA交联，而不是中国仓鼠细胞。仓鼠细胞中没有链间交联的不存在并不是由于缺乏药物摄取，而是由于其未能转化（可能是通过生物学的）CB 1954将其转化为所需的反应性韧性中间体。
Walker tumour cells were shown to be uniquely sensitive to CB 1954 when compared with other cells in vitro. CB 1954 forms DNA-DNA interstrand crosslinks in a time-dependent manner in Walker tumour but not Chinese hamster cells. The absence of interstrand crosslinks in hamster cells was not due to a lack of uptake of drug but rather to a their failure to convert (probably by bioreduction) CB 1954 to the required reactive difunctional intermediate.