Effects of feed-borne Fusarium mycotoxins with or without yeast cell wall adsorbent on organ weight, serum biochemistry, and immunological parameters of broiler chickens
Effects of feed-borne Fusarium mycotoxins with or without yeast cell wall adsorbent on organ weight, serum biochemistry, and immunological parameters of broiler chickens
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DOI：
10.3382/ps.2012-02437
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发表时间：
2012-10-01
期刊：
影响因子：
4.4
通讯作者：
Wu, Y. B.
中科院分区：
文献类型：
--
作者：
Li, Z.;Yang, Z. B.;Wu, Y. B.
本研究旨在研究饲用镰刀菌毒素对肉鸡器官重量、血清生化和免疫学指标的毒性作用，并评价酵母细胞壁吸附剂预防霉菌毒素所致不良反应的效果。将300只1日龄接种马立克氏病和传染性支气管炎疫苗的Arbor Acres肉鸡(混合性别)随机分为3个处理(每个处理5个重复)，分别饲喂基础日粮和天然污染日粮，添加或不添加酵母细胞壁吸附剂。处理为对照组、自然污染饲料(NCD；黄曲霉毒素，102.08 mg/kg；玉米赤霉烯酮，281.92 mg/kg；伏马菌素，5874.38 mg/kg；脱氧雪腐镰刀菌烯醇，2038.96 mg/kg)，以及NCD+2g/kg酵母细胞壁吸附剂(NCDD)。试验分两个阶段：d0-21和d22-42。与对照组相比，NCD组在42日龄时血清白蛋白升高(P<；0.05)，肝脏、法氏囊和胸腺的相对重量以及脾组织中IL-1β和IL-6的mRNA表达增加(P<；0.05)，而在42日龄时降低(P<；0.05)血清球蛋白、21d的IgA、21d的脾相对重量、28d和42日龄的新城疫抗体效价以及42日龄的脾组织中干扰素-γ的mRNA表达。日粮中添加酵母细胞壁吸附剂对21日龄肝脾相对重量、42日龄法氏囊和胸腺相对重量、28日龄和42日龄新城疫抗体效价、42日龄脾组织中IL-1β、IL-6和干扰素-γ的mRNA表达均有正保护作用，提示饲喂天然污染日粮42d可能对肉鸡产生不良影响，添加2g/kg酵母细胞壁肠粘附剂可部分中和天然污染饲料的危害。
The objectives of the present study were to investigate the toxicity of feed-borne Fusarium mycotoxins on organ weight, serum biochemistry, and immunological parameters of broiler chickens and to evaluate the efficacy of yeast cell wall adsorbent in preventing mycotoxin-induced adverse effects. In total, 300 one-day-old vaccinated (Marek's disease and infectious bronchitis) Arbor Acres broiler chickens (mixed sex) were randomly divided into 3 treatments (5 repetitions per treatment) and fed basal diet and naturally contaminated diets with or without yeast cell wall adsorbent. Treatments were control, naturally contaminated diet (NCD; aflatoxin, 102.08 mg/kg; zearalenone, 281.92 mg/kg; fumonisin, 5,874.38 mg/kg; deoxynivalenol, 2,038.96 mg/kg), and NCD + 2 g/kg of yeast cell wall adsorbent (NCDD). The test included 2 phases: d 0-21 and d 22-42. At 42 d, broilers fed contaminated diets without yeast cell wall adsorbent had higher (P < 0.05) serum albumin and higher relative weight of liver, bursa of Fabricius, and thymus, and greater splenic mRNA expression of IL-1 beta and IL-6 at 42 d compared with the control, but lower (P < 0.05) serum globulin at 42 d, IgA at 21 d, relative weight of spleen at 21 d, antibody titers of Newcastle disease at both 28 d and 42 d, and splenic mRNA expression of IFN-gamma at 42 d were observed in the NCD treatment compared with control. Dietary addition of yeast cell wall adsorbent in the NCD treatment showed a positive protection effect on the relative weight of the liver and spleen at 21 d, relative weight of the bursa of Fabricius and thymus at 42 d, antibody titers of Newcastle disease at both 28 d and 42 d, and splenic mRNA expression of IL-1 beta, IL-6, and IFN-gamma at 42 d. It is suggested that feeding a naturally contaminated diet for 42 d might result in a deleterious effect in broiler chickens, and addition of 2 g/kg of yeast cell wall enterosorbent can partly neutralize the detrimental effects of the naturally contaminated feed.