Morphofunctional Organization of the Connections From the Medial and Intermediate Parts of the Central Nucleus of the Amygdala Into Distinct Divisions of the Lateral Hypothalamic Area in the Rat
Morphofunctional Organization of the Connections From the Medial and Intermediate Parts of the Central Nucleus of the Amygdala Into Distinct Divisions of the Lateral Hypothalamic Area in the Rat
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DOI：
10.3389/fneur.2018.00688
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发表时间：
2018-08-24
影响因子：
3.4
通讯作者：
Risold, Pierre-Yves
中科院分区：
文献类型：
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作者：
Barbier, Marie;Fellmann, Dominique;Risold, Pierre-Yves
杏仁中央核（CEA）向下丘脑外侧区（LHA）的投射呈现出非常复杂的模式。注射顺行示踪剂（菜豆leucoagglutinin- PHAL）到CEA的内侧和中间部分后，我们观察到标记的轴突汇聚到尾侧LHA，但在喙结节区域提供不同的模式。这些预测进行了比较，含有肽“黑色素浓缩激素”（MCH）或下丘脑泌素（Hcrt）的神经元。由于这些神经元的分布是定型的，因此可以将其划分为LHA。它们中的一些在喙结节LHA [背侧（LHAd）和穹隆上区（LHAs）]接受了不同的神经支配的投射，分别来自前或后区的内侧部分（CEAm）或从中间部分（CEAi）的中央核。因此，这项工作表明，从CEAm和CEAi的投影收敛到尾侧LHA，但分叉到喙结节LHA。
Projections from the central nucleus of the amygdala (CEA) into the lateral hypothalamic area (LHA) show a very complex pattern. After injection of an anterograde tracer (Phaseolus vulgaris leucoagglutinin- PHAL) into the medial and intermediate parts of the CEA, we observed that labeled axons converged onto the caudal lateral LHA but provided distinct patterns in rostral tuberal regions. These projections were compared to that of neurons containing the peptides "melanin-concentrating hormone" (MCH) or hypocretin (Hcrt). Because the distribution of these neurons is stereotyped, it was possible to characterize distinct divisions into the LHA. Some of them in the rostral tuberal LHA [the dorsal (LHAd) and suprafornical regions (LHAs)] received a distinct innervation by projections that originated from neurons in respectively anterior or posterior regions of the medial part (CEAm) or from the intermediate part (CEAi) of the central nucleus. Therefore, this work illustrates that projections from the CEAm and CEAi converge into the caudal lateral LHA but diverge into the rostral tuberal LHA.