Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio)
Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio)
复制标题
双酚 S 暴露对斑马鱼幼虫 (Danio rerio) 生命早期阶段神经行为的影响。
DOI：
10.1016/j.chemosphere.2018.10.218
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发表时间：
2019-02-01
期刊：
影响因子：
8.8
通讯作者：
Ji, Guixiang
中科院分区：
文献类型：
--
作者：
Gu, Jie;Zhang, Jiayao;Ji, Guixiang
双酚S（BPS）作为双酚A（BPA）的替代品，目前广泛用于生产我们的日常消费品。一些研究表明，BPS 有可能破坏生殖和葡萄糖稳态。然而，BPS 对神经系统的影响仍不清楚。本研究的目的是调查 BPS 对斑马鱼早期生长阶段神经系统的影响。 BPS 对斑马鱼幼虫的 96 h-LC50 值为 323 mg/L (95%CI: 308-339 mg/L)。斑马鱼胚胎暴露于浓度为 0、0.03、0.3 和 3.0 mg/L 的 BPS 直至受精后 6 天。我们的结果表明，0.3 和 3.0 mg/L BPS 暴露显着降低了斑马鱼的运动行为，伴随着氧化应激增加、促进细胞凋亡并改变了视网膜结构。此外，6种神经发育基因（α1-微管蛋白、elavl3、gap43、mbp、syn2a和gfap）的表达水平在3.0 mg/L BPS处理后下调。总之，BPS 可能部分通过增加氧化应激和抑制神经发育基因的表达水平来影响斑马鱼幼虫的运动行为并改变视网膜结构。 (C) 2018 Elsevier Ltd. 保留所有权利。
As an alternate of bisphenol A (BPA), bisphenol S (BPS) is now widely used to produce our daily consumer goods. Some studies have shown that BPS has the potential to disrupt the reproduction and glucose homeostasis. However, the impact of BPS on the nervous system remains unclear. The purpose of this study is to investigate the impact of BPS on the nervous systems of zebrafish in their early growing stages. The 96 h-LC50 value of BPS to zebrafish larvae was 323 mg/L (95%CI: 308-339 mg/L). Zebrafish embryos were exposed to BPS at concentrations of 0, 0.03, 0.3 and 3.0 mg/L until 6 days postfertilization. Our results showed that 0.3 and 3.0 mg/L BPS exposure markedly decreased locomotor behavior, accompany by the increased oxidative stress, promoted apoptosis and altered retinal structure in zebrafish. In addition, the expression levels of six neurodevelopment genes (alpha 1 -tubulin, elavl3, gap43, mbp, syn2a and gfap) were downregulated after 3.0 mg/L BPS treatment. In conclusion, BPS may affect locomotor behavior and alter retinal structure in zebrafish larvae partially by increasing oxidative stress, and by suppressing the expression levels of neurodevelopment genes. (C) 2018 Elsevier Ltd. All rights reserved.