URIC-ACID AND CORONARY HEART-DISEASE RISK - EVIDENCE FOR A ROLE OF URIC-ACID IN THE OBESITY-INSULIN RESISTANCE SYNDROME
URIC-ACID AND CORONARY HEART-DISEASE RISK - EVIDENCE FOR A ROLE OF URIC-ACID IN THE OBESITY-INSULIN RESISTANCE SYNDROME
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尿酸与冠心病风险--尿酸在肥胖-胰岛素抵抗综合征中发挥作用的证据
DOI：
10.1093/oxfordjournals.aje.a117634
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发表时间：
1995-08-01
影响因子：
5
通讯作者：
WEISS, ST
中科院分区：
文献类型：
--
作者：
LEE, J;SPARROW, D;WEISS, ST
各种流行病学研究已经将血清尿酸水平的升高与冠心病风险的增加联系起来，这一发现的原因尚不清楚，作者检查了一些心血管疾病危险因素对886名参加规范老龄化研究的中老年男性血清尿酸水平的影响。在预测血清尿酸水平的多元回归模型中，尿酸与身体质量指数(体重(kg)/身高(m)呈正相关(2)；每公斤β= 0.041 mg / dl / m (2), p = 0003),腹部:臀围比例(β= 1.88 mg / dl / cm / cm, p = 0.048),日志饮酒(β= 0.150 mg / dl / g /星期,p = 0.0001),和日志postcarbohydrate胰岛素水平(β= 0.157 mg / dl /日志(μ陆/毫升),p = 0.005),血清尿酸水平随着年龄的增长负相关(β= -0.012 mg / dl每年的年龄,p = 0.017)和日志身体活动(β= -0.152 mg / dl /千卡/星期,p = 0.0001),这些数据提示血清尿酸可能参与肥胖-胰岛素抵抗综合征，进而解释血清尿酸与冠状动脉粥样硬化的关系。
Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease, The reasons for this finding are unclear, The authors examined the influence of a number of cardiovascular disease risk factors on serum uric acid level in 886 middle-aged and older men participating in the Normative Aging Study. The men were examined between 1987 and 1991, In a multivariate regression model predicting serum uric acid level, uric acid was positively associated with body mass index (weight (kg)/height (m)(2); beta = 0.041 mg/dl per kg/m(2), p = 0,003), abdomen:hip circumference ratio (beta = 1.88 mg/dl per cm/cm, p = 0.048), log alcohol intake (beta = 0.150 mg/dl per g/week, p = 0.0001), and log postcarbohydrate insulin level (beta = 0.157 mg/dl per log(mu lU/ml), p = 0.005), Serum uric acid level was negatively associated with age (beta = -0.012 mg/dl per year of age, p = 0.017) and log physical activity (beta = -0.152 mg/dl per kcal/week, p = 0.0001), The data suggest that serum uric acid may be involved in the obesity-insulin resistance syndrome, which in turn may explain the relation of serum uric acid to coronary atherosclerosis.