Randomized trial of the effectiveness of combined behavioral/pharmacological smoking cessation treatment in Syrian primary care clinics.
Randomized trial of the effectiveness of combined behavioral/pharmacological smoking cessation treatment in Syrian primary care clinics.
复制标题
叙利亚初级保健诊所行为/药物联合戒烟治疗有效性的随机试验。
DOI：
10.1111/j.1360-0443.2012.04048.x
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Maziak,Wasim
中科院分区：
文献类型：
--
作者：
Ward,KennethD;Asfar,Taghrid;AlAli,Radwan;Rastam,Samer;Weg,MarkWVander;Eissenberg,Thomas;Maziak,Wasim
AimsEffectiveness of nicotine replacement therapy (NRT) for smoking cessation has not been evaluated in low income countries, such as Syria, where it is expensive and not widely available. We evaluated whether nicotine patch boosts smoking cessation rates when used in conjunction with behavioral support in primary care clinics in Aleppo, Syria.DesignTwo arm, parallel group, randomized, placebo controlled, double‐blinded multi‐site trial.SettingFour primary care clinics in Aleppo, Syria.ParticipantsTwo hundred and sixty‐nine adult primary care patients received behavioral cessation counseling from a trained primary care physician and were randomized to receive six weeks of treatment with nicotine versus placebo patch.MeasurementsPrimary end‐points were prolonged abstinence (no smoking after a 2‐week grace period) at end of treatment, and 6 and 12 months post‐quit day, assessed by self‐report and exhaled carbon monoxide levels of <10 p.p.m.FindingsTreatment adherence was excellent and nicotine patch produced expected reductions in urges to smoke and withdrawal symptoms, but no treatment effect was observed. The proportion of patients in the nicotine and placebo groups with prolonged abstinence was 21.6% and 20.0%, respectively, at end of treatment, 13.4% and 14.1% at 6 months, and 12.7% and 11.9% at 12 months.ConclusionsNicotine patches may not be effective in helping smokers in low‐income countries to stop when given as an adjunct to behavioural support.
