Early behavioral symptoms and course of Alzheimer's disease
Early behavioral symptoms and course of Alzheimer's disease
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DOI：
10.1111/j.1600-0447.2004.00472.x
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发表时间：
2005-05-01
影响因子：
6.7
通讯作者：
White, C
中科院分区：
文献类型：
--
作者：
Weiner, MF;Hynan, LS;White, C
目的：确定在初始评估中检测到的行为症状是否与阿尔茨海默病（AD）患者的认知或功能状态或生存时间有关。方法：回顾100例尸检证实的AD患者，初步评估时发现的行为症状与认知和整体功能测量以及生存时间的关系。结果：74%的患者出现行为症状，包括冷漠（51%）、幻觉（25%）、妄想（20%）和抑郁情绪（6.6%）。言语攻击较为常见（36.8%）；身体攻击较少（17%）。与无症状组相比，有症状组功能受损更严重（但没有认知障碍），中位生存时间更短（8年：95% CI: 7-9年vs. 10年：95% CI: 8-12年；P = 0.002）。在最初的评估中，任何一种症状的出现占疾病持续时间变异的6.1%。结论：AD患者初始评估时行为症状的存在与较大的功能损害和较短的生存时间相关。
Objective: To determine if behavioral symptoms detected at initial evaluation relate to cognitive or functional status or survival time in Alzheimer's disease (AD) patients.Method: Review, in 100 cases of autopsy-proven AD, of the relationship of behavioral symptoms detected at initial evaluation to cognitive and global function measures and survival time.Results: Behavioral symptoms had occurred in 74% of patients, including apathy (51%), hallucinations (25%), delusions (20%) and depressed mood (6.6%). Verbal aggression was common (36.8%); physical aggression less so (17%). The symptomatic group was more functionally (but not cognitively) impaired and had shorter median survival time (8 years: 95% CI: 7-9 years vs. 10 years: 95% CI: 8-12 years; P = 0.002) than the asymptomatic group. The presence of any one symptom at initial evaluation accounted for 6.1% of the variance in duration of illness.Conclusion: Presence of behavioral symptoms at initial evaluation of AD patients is associated with greater functional impairment and shorter survival time.