Caenorhabditis elegas genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33
Caenorhabditis elegas genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33
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DOI：
10.1534/genetics.108.087221
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发表时间：
2008-05-01
期刊：
影响因子：
3.3
通讯作者：
Horvitz, H. Robert
中科院分区：
文献类型：
--
作者：
Galvin, Brendan D.;Kim, Saechin;Horvitz, H. Robert
在秀丽隐杆线虫中已经广泛研究了两种类型的细胞死亡，程序性细胞死亡和坏死。我们描述了一种新的细胞死亡类型，发生在两个基因lin-24和lin-33中含有突变的动物中。lin-24和lin-33中的功能获得性突变导致许多Pn. p皮下胚细胞的不适当死亡，并阻止存活的Pn. p细胞表达其正常发育命运。在lin-24和lin-33突变体动物中的异常Pn. p细胞在形态上不同于C.程序性细胞死亡和坏死性细胞死亡。lin-24编码与细菌毒素具有同源性的蛋白质。lin-33编码一种新的蛋白。由任一基因突变引起的细胞毒性需要另一个基因的功能。一组进化上保守的基因需要有效的吞噬和清除凋亡和坏死的细胞尸体是需要的突变lin-24和lin-33基因的全部细胞杀伤作用，这表明吞噬促进这些细胞毒性细胞死亡。
Two types of cell death have been studied extensively in Caenorhabditis elegans, programmed cell death and necrosis. We describe a novel type of cell death that occurs in animals containing mutations in either of two genes, lin-24 and lin-33. Gain-of-function mutations in lin-24 and lin-33 cause the inappropriate deaths of many of the Pn.p hypodermal blast cells and prevent the surviving Pn.p cells from expressing their normal developmental fates. The abnormal Pn.p cells in lin-24 and lin-33 mutant animals are morphologically distinct from the dying cells characteristic of C. elegans programmed cell deaths and necrotic cell deaths. lin-24 encodes a protein with homology to bacterial toxins. lin-33 encodes a novel protein. The cytotoxicity caused by mutation of either gene requires the function of the other. An evolutionarily conserved set of genes required for the efficient engulfment and removal of both apoptotic and necrotic cell corpses is required for the full cell-killing effect of mutant lin-24 and lin-33 genes, suggesting that engulfment promotes these cytotoxic cell deaths.